帕金森病伴视幻觉患者的皮质和皮质下脑萎缩。
Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination.
机构信息
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
出版信息
Mov Disord. 2013 Oct;28(12):1732-6. doi: 10.1002/mds.25641. Epub 2013 Oct 21.
BACKGROUND
The aim of this study was to investigate the cortical and subcortical brain structures in Parkinson's disease (PD) with visual hallucination (VH), and to elucidate the association between the proposed hypothesis of VH in PD and regional brain volume changes.
METHODS
We used 3T magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) to investigate the brain structures of PD patients with VH (PD-VH; n = 13) and PD patients without VH (PD-C; n = 13).
RESULTS
The PD-VH patients showed significant cortical atrophy compared to the PD-C patients in the bilateral dorsolateral prefrontal cortex, left rostral region of the prefrontal cortex, left ventral section of the cingulate cortex, bilateral primary visual cortex, and secondary visual cortex including the left inferior occipital gyrus, right lingual cortex, right supramarginal gyrus, and left fusiform gyrus. Significant subcortical atrophic changes were observed in the white matter of the right parahippocampal gyrus, the bilateral posterior part of the cingulate gyrus, the left lingual gyrus, and the right middle occipital gyrus.
CONCLUSIONS
VH in PD can occur due to distinctive neuroanatomical involvement.
背景
本研究旨在探讨伴有视觉幻觉（VH）的帕金森病（PD）患者的皮质和皮质下脑结构，并阐明 PD 中 VH 假说与局部脑容量变化之间的关联。
方法
我们使用 3T 磁共振成像（MRI）和基于体素的形态测量学（VBM）来研究伴有 VH 的 PD 患者（PD-VH；n=13）和不伴有 VH 的 PD 患者（PD-C；n=13）的脑结构。
结果
与 PD-C 患者相比，PD-VH 患者双侧背外侧前额叶皮质、左侧额前皮质的额极、左侧扣带回腹侧部分、双侧初级视觉皮质和包括左侧下枕叶、右侧舌回、右侧缘上回和左侧梭状回在内的二级视觉皮质出现明显的皮质萎缩。右侧海马旁回白质、双侧扣带回后部、左侧舌回和右侧中枕叶的皮质下白质也出现明显的萎缩性改变。
结论
PD 中的 VH 可能是由于独特的神经解剖结构参与所致。
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