Wang Yaxi, Li Dongfeng, Chen Yaning, Zhu Sha, Jiang Xu, Jiang Yinyin, Gu Ruxin, Shen Bo, Zhu Jun, Pan Yang, Yan Jun, Zhang Li
Department of Geriatric Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Front Neurol. 2023 Mar 24;14:1158188. doi: 10.3389/fneur.2023.1158188. eCollection 2023.
Minor hallucinations (MHs) are the most common psychiatric symptom associated with Parkinson's disease (PDPsy), but little is known about their characteristics in different motor phenotypes, especially postural instability gait difficulty (PIGD). The aim of this study was to explore the clinical features of MHs in different subtypes of PD.
In this cross-sectional study, 213 patients with Parkinson's disease (PD) were recruited, and the data obtained included comprehensive demographics, motor subtypes, clinical scale scores, and MH contents. Motor subtypes were classified as tremor-dominant (TD), PIGD or indeterminate according to Stebbins' method.
A total of 213 PD patients were included: 90 (42.3%) TD patients, 98 (46.0%) PIGD patients and 25 (11.7%) indeterminate. In total, 70 (32.9%) patients experienced MHs. Compared to patients with the TD phenotype, we found that patients with the PIGD phenotype had more severe motor and nonmotor symptoms. They also had a higher incidence of visual illusions (VIs) and a shorter MH latency.
Our study demonstrated that compared to patients with the TD phenotype, patients with the PIGD phenotype had a higher incidence of MHs, especially VIs, which may lead to a higher incidence of visual hallucinations (VHs). They also had a shorter latency of MHs than patients with the TD phenotype, suggesting an earlier onset of MHs and a worse prognosis.
轻微幻觉（MHs）是帕金森病伴发精神症状（PDPsy）最常见的精神症状，但对于其在不同运动表型中的特征，尤其是姿势不稳步态障碍（PIGD），人们知之甚少。本研究旨在探讨帕金森病不同亚型中MHs的临床特征。
在这项横断面研究中，招募了213例帕金森病（PD）患者，收集的数据包括全面的人口统计学信息、运动亚型、临床量表评分和MHs内容。根据斯特宾斯方法，将运动亚型分为震颤为主型（TD）、PIGD型或不确定型。
共纳入213例PD患者：90例（42.3%）TD型患者，98例（46.0%）PIGD型患者，25例（11.7%）不确定型患者。总共有70例（32.9%）患者出现MHs。与TD表型患者相比，我们发现PIGD表型患者有更严重的运动和非运动症状。他们还具有更高的视幻觉（VIs）发生率和更短的MH潜伏期。
我们的研究表明，与TD表型患者相比，PIGD表型患者MHs的发生率更高，尤其是VIs，这可能导致更高的视幻觉（VHs）发生率。他们的MHs潜伏期也比TD表型患者短，提示MHs发病更早且预后更差。
