Imashuku S, Takada H, Sawada T, Kusunoki T
Clin Chim Acta. 1975 Aug 18;63(1):1-5. doi: 10.1016/0009-8981(75)90370-8.
Catecholamine biosynthesis in tumor cells was studied in four patients, who expired from disseminated neuroblastoma. 1. The activity of tyrosine hydroxylase was detected in tumor tissues of all but one patient. 2. Dopamine-beta-hydroxylase activity was assayabel in almost all tissues, except in the primary tumor of one patient. 3. The enzyme activities in the metastatic lesions were at the same levels in two cases, but much higher in the other two cases, as those in the primary tumours. 4. It was learned that the urinary excretion of vanilmandelic acid (VMA) and homovanillic acid (HVA) in these patients reflects the tissue levels of catecholamine synthesizing enzymes as well as the tumor mass.
对四名因播散性神经母细胞瘤死亡的患者的肿瘤细胞中的儿茶酚胺生物合成进行了研究。1. 除一名患者外，其他所有患者的肿瘤组织中均检测到酪氨酸羟化酶的活性。2. 除一名患者的原发性肿瘤外，几乎所有组织中均可检测到多巴胺-β-羟化酶的活性。3. 两例转移病灶中的酶活性与原发性肿瘤中的酶活性处于相同水平，但另外两例转移病灶中的酶活性比原发性肿瘤中的酶活性高得多。4. 据了解，这些患者尿中香草扁桃酸（VMA）和高香草酸（HVA）的排泄反映了儿茶酚胺合成酶的组织水平以及肿瘤块大小。
