West John G, Kapoor Nimmi S, Liao Shu-Yuan, Chen June W, Bailey Lisa, Nagourney Robert A
Breastlink, Department of Surgery, 230 S. Main Street, Suite 100, Orange, CA 92868, USA.
Case Rep Med. 2013;2013:354682. doi: 10.1155/2013/354682. Epub 2013 Sep 18.
Breast cancer occurring in women under the age of 40 is uncommon in the absence of family history or genetic predisposition, and prompts the exploration of other possible exposures or environmental risks. We report a case series of four young women-ages from 21 to 39-with multifocal invasive breast cancer that raises the concern of a possible association with nonionizing radiation of electromagnetic field exposures from cellular phones. All patients regularly carried their smartphones directly against their breasts in their brassieres for up to 10 hours a day, for several years, and developed tumors in areas of their breasts immediately underlying the phones. All patients had no family history of breast cancer, tested negative for BRCA1 and BRCA2, and had no other known breast cancer risks. Their breast imaging is reviewed, showing clustering of multiple tumor foci in the breast directly under the area of phone contact. Pathology of all four cases shows striking similarity; all tumors are hormone-positive, low-intermediate grade, having an extensive intraductal component, and all tumors have near identical morphology. These cases raise awareness to the lack of safety data of prolonged direct contact with cellular phones.
在没有家族病史或遗传易感性的情况下,40岁以下女性患乳腺癌的情况并不常见,这促使人们探索其他可能的暴露因素或环境风险。我们报告了一组4例年轻女性(年龄在21至39岁之间)多灶性浸润性乳腺癌的病例系列,这引发了人们对其与手机产生的电磁场非电离辐射可能存在关联的担忧。所有患者多年来每天有长达10小时的时间将智能手机直接放在胸罩里紧贴乳房携带,并在手机紧贴乳房的部位发生了肿瘤。所有患者均无乳腺癌家族史,BRCA1和BRCA2检测均为阴性,且无其他已知的乳腺癌风险因素。对她们的乳腺影像学检查进行回顾,发现手机接触区域正下方的乳房内多个肿瘤病灶聚集。所有4例病例的病理表现惊人地相似;所有肿瘤均为激素阳性、低-中级别,具有广泛的导管内成分,且所有肿瘤的形态几乎相同。这些病例提高了人们对长时间直接接触手机缺乏安全数据的认识。