School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Analyst. 2013 Dec 7;138(23):7140-5. doi: 10.1039/c3an01233f.
Saccharides - a versatile class of biologically important molecules - are involved in a variety of physiological and pathological processes, but their detection and quantification is challenging. Herein, surface plasmon resonance and self-assembled monolayers on gold generated from bis-boronic acid bearing a thioctic acid moiety, whose intramolecular distance between the boronic acid moieties is well defined, are shown to detect d-glucose with high selectivity, demonstrating a higher affinity than other saccharides probed, namely d-galactose, d-fructose and d-mannose.
糖 - 一类具有广泛用途的生物重要分子 - 参与了各种生理和病理过程，但它们的检测和定量具有挑战性。在此，展示了基于带有硫辛酸部分的双硼酸的表面等离子体共振和金的自组装单层，其硼酸部分之间的分子内距离是明确的，对 d-葡萄糖具有高选择性的检测，表现出比其他被探测的糖（即 d-半乳糖、d-果糖和 d-甘露糖）更高的亲和力。
