Krohne G, Benavente R
Exp Cell Res. 1986 Jan;162(1):1-10. doi: 10.1016/0014-4827(86)90421-0.
The nuclear lamina consists of a proteinaceous layer or meshwork situated subjacent to the inner nuclear membrane. It is a karyoskeletal structure formed by a polymer containing one to three major polypeptides collectively termed the lamins. In all cells examined of vertebrates and invertebrates, the lamins exhibit very similar Mr ranging from 60 000 to 80 000. In vertebrates, two groups of lamins can be distinguished by their isoelectric value, one being near-neutral and the other acidic (isoelectric pH values of 5.6 and lower). The lamins represent a family of polypeptides with regions highly conserved during evolution. In certain species, e.g., the amphibian, Xenopus laevis, they exhibit cell type-specific expression during embryonic development, terminal differentiation of certain somatic cells, and gametogenesis. The nuclear lamina of diverse cell types can be composed of one, two or three different lamin polypeptides, without obvious differences in its morphology.
核纤层由位于内核膜下方的蛋白质层或网络组成。它是一种核骨架结构，由一种聚合物形成，该聚合物包含一到三种主要多肽，统称为核纤层蛋白。在所有已检测的脊椎动物和无脊椎动物细胞中，核纤层蛋白的分子量非常相似，范围在60000到80000之间。在脊椎动物中，两组核纤层蛋白可根据其等电值区分，一组接近中性，另一组呈酸性（等电pH值为5.6及更低）。核纤层蛋白代表了一类在进化过程中具有高度保守区域的多肽家族。在某些物种中，例如两栖动物非洲爪蟾，它们在胚胎发育、某些体细胞的终末分化和配子发生过程中表现出细胞类型特异性表达。不同细胞类型的核纤层可由一种、两种或三种不同的核纤层蛋白多肽组成，其形态无明显差异。
