Tintelnot K
Konsiliarlabor für Kryptokokkose, Scedosporiose und importierte Systemmykosen, Robert Koch-Institut, Nordufer 20, 13353, Berlin, Deutschland,
Pathologe. 2013 Nov;34(6):503-10. doi: 10.1007/s00292-013-1829-3.
Usually the detection of hyphae in tissue is unmistakable evidence of a deep mycosis requiring antimycotic treatment. Micromorphology alone rarely allows a specific diagnosis, thus confusion is possible between Candida, Aspergillus, Alternaria and Fusarium species or several other fungal agents. If broad, nearly non-septated hyphae are detected histologically mucormycosis can be suspected. Detection of hyphae in tissue is always a cause for concern because therapeutic consequences must follow. Because therapeutic strategies may differ depending on the specific fungal agent, a suspected diagnosis should be supplemented by other methods, e.g. culture of unfixed specimens, by immunohistology or molecular biological methods.
通常，在组织中检测到菌丝是深部真菌病需要抗真菌治疗的确切证据。仅凭微观形态学很少能做出特异性诊断，因此念珠菌、曲霉菌、链格孢属和镰刀菌属或其他几种真菌病原体之间可能会出现混淆。如果在组织学上检测到宽大、几乎无隔膜的菌丝，则可怀疑为毛霉病。在组织中检测到菌丝总是令人担忧的，因为必须采取治疗措施。由于治疗策略可能因具体的真菌病原体而异，疑似诊断应通过其他方法进行补充，例如未固定标本的培养、免疫组织学或分子生物学方法。
