Université Paris Descartes, Service d'Hématologie Adultes, Hôpital Necker-Enfants Malades, AP-HP, 149 Rue de Sèvres, 75743 Paris Cedex 15, France.
J Clin Microbiol. 2011 Jan;49(1):461-5. doi: 10.1128/JCM.01213-10. Epub 2010 Nov 10.
Hormographiella aspergillata, a filamentous basidiomycete, has rarely been involved in human infections. We describe 2 febrile neutropenic patients who developed a severe pulmonary infection due to H. aspergillata while receiving empirical caspofungin therapy for presumed fungal pneumonia. After introduction of liposomal amphotericin B, one patient, who had neutrophil recovery, presented a favorable outcome, while the other, who remained neutropenic throughout the course of infection, died. Resistant fungi, including basidiomycetes, may emerge during empirical treatment with caspofungin in febrile neutropenic patients. A rapid switch to any other potent antifungal should be rapidly considered in case of failure of caspofungin in this setting.
aspergillata 是一种丝状担子菌，很少引起人类感染。我们描述了 2 例发热性中性粒细胞减少症患者，他们在接受经验性卡泊芬净治疗疑似真菌性肺炎时，因感染 H. aspergillata 而发生严重肺部感染。在使用脂质体两性霉素 B 后，1 例中性粒细胞恢复的患者结果良好，而另 1 例在整个感染过程中持续中性粒细胞减少的患者则死亡。在发热性中性粒细胞减少症患者中，经验性使用卡泊芬净可能会出现耐药真菌，包括担子菌。在这种情况下，如果卡泊芬净治疗失败，应迅速考虑快速切换为任何其他强效抗真菌药物。
