Bello Nusirat, Winit-Watjana Win, Baqir Wasim, McGarry Kenneth
Department of Pharmacy, Health and Well-being (PHW), University of Sunderland , Sunderland ( United Kingdom ).
Pharm Pract (Granada). 2012 Jul;10(3):125-35. doi: 10.4321/s1886-36552012000300002. Epub 2012 Sep 30.
This study aimed to investigate the prevalence, disclosure and adverse effects of complementary and alternative medicine (CAM) use in hospitalised patients, and to explore the associations between patients' perceived side-effects and relevant factors.
Patients who were admitted to a district general hospital and met the eligibility criteria were interviewed using a semi-structured questionnaire. Their medications and pertinent details were verified from the medical notes. All quantitative and qualitative data were collated and analysed. A chi-squared test was performed to test the associations of the perceived CAM side-effects with the significance level determined at α=0.05.
A total of 240 in-patients completed the study. They were mostly white British (98.8%). The prevalence of CAM use within two years was 74.6% and one month 37.9%. Only 19 of 91 patients (20.9%) using CAM within one month disclosed their current CAM applications. Nearly half of patients (45.8%) who used CAM within two years experienced various CAM side-effects that tended to resolve after discontinuation. Slightly more than half (57.6%) perceived CAM side-effects and their perceptions were significantly associated with gender (P=0.048) and consideration for future CAM use (P=0.033). Potential interactions between herbal remedies/dietary supplements and prescribed drugs, such as garlic with lisinopril or aspirin, were assessed in 82 patients (45.8%).
Most in-patients used CAM and experienced some adverse effects. The disclosure of CAM use and its adverse outcomes should be encouraged by healthcare professionals.
本研究旨在调查住院患者使用补充和替代医学（CAM）的患病率、披露情况及不良反应，并探讨患者感知的副作用与相关因素之间的关联。
对入住地区综合医院且符合入选标准的患者采用半结构化问卷进行访谈。从病历中核实他们的用药情况及相关细节。对所有定量和定性数据进行整理和分析。进行卡方检验以检验感知的CAM副作用与在α = 0.05确定的显著性水平之间的关联。
共有240名住院患者完成了研究。他们大多是英国白人（98.8%）。两年内CAM的使用率为74.6%，一个月内为37.9%。在一个月内使用CAM的91名患者中，只有19名（20.9%）披露了他们当前的CAM使用情况。两年内使用CAM的患者中近一半（45.8%）经历了各种CAM副作用，停药后这些副作用往往会缓解。略多于一半（57.6%）的患者感知到CAM副作用，且他们的感知与性别（P = 0.048）和未来使用CAM的考虑因素（P = 0.033）显著相关。在82名患者（45.8%）中评估了草药/膳食补充剂与处方药之间的潜在相互作用，如大蒜与赖诺普利或阿司匹林之间的相互作用。
大多数住院患者使用CAM并经历了一些不良反应。医疗保健专业人员应鼓励披露CAM的使用情况及其不良后果。
