对实质自身的耐受性。主要组织相容性复合体限制的、针对自体肾小管抗原的OX8 +抑制性T细胞在实验性间质性肾炎中的调节作用。
Tolerance to parenchymal self. Regulatory role of major histocompatibility complex-restricted, OX8+ suppressor T cells specific for autologous renal tubular antigen in experimental interstitial nephritis.
作者信息
Kelly C J, Silvers W K, Neilson E G
出版信息
J Exp Med. 1985 Dec 1;162(6):1892-903. doi: 10.1084/jem.162.6.1892.
Abstract
BN rats develop interstitial nephritis after immunization with rabbit, but not rat renal tubular antigen. Using RT1n rat strains that differentially express tubular antigen, we investigated the unresponsiveness of BN rats to BN tubular antigen (BN-TBM) using delayed-type hypersensitivity (DTH) responses to BN-TBM as a measure of cell-mediated immunity. Our results indicate that rat strains expressing tubular antigen respond to immunization with BN-TBM with the clonal expansion of antigen-specific, cyclophosphamide-sensitive, OX8+, MHC-restricted suppressor T cells. Such suppression appears to be relevant to the maintenance of tolerance to parenchymal self, since chronic cyclophosphamide therapy abrogates suppression and results in significant interstitial nephritis.
摘要
用兔肾小管抗原而非大鼠肾小管抗原免疫后，BN大鼠会发生间质性肾炎。利用差异表达肾小管抗原的RT1n大鼠品系，我们以对BN肾小管基底膜（BN-TBM）的迟发型超敏反应（DTH）作为细胞介导免疫的指标，研究了BN大鼠对BN肾小管抗原（BN-TBM）的无反应性。我们的结果表明，表达肾小管抗原的大鼠品系在接受BN-TBM免疫后，抗原特异性、对环磷酰胺敏感、OX8 +、主要组织相容性复合体（MHC）限制的抑制性T细胞会发生克隆性扩增。这种抑制作用似乎与维持对实质自身的耐受性有关，因为慢性环磷酰胺治疗可消除抑制作用，并导致严重的间质性肾炎。
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