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1
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J Exp Med. 1985 Dec 1;162(6):2175-9. doi: 10.1084/jem.162.6.2175.
2
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3
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N Engl J Med. 1985 Dec 5;313(23):1429-33. doi: 10.1056/NEJM198512053132301.
4
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Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia.费城染色体阳性急性淋巴细胞白血病中bcr和c-abl基因的独特融合
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6
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Blut. 1987 Dec;55(6):505-11. doi: 10.1007/BF00320220.
7
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8
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C-abl and bcr are rearranged in a Ph1-negative CML patient.在一名Ph1阴性慢性粒细胞白血病患者中，C-abl和bcr发生了重排。
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Leuk Res. 1986;10(2):221-5. doi: 10.1016/0145-2126(86)90045-7.

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Nilotinib first-line therapy in patients with Philadelphia chromosome-negative/BCR-ABL-positive chronic myeloid leukemia in chronic phase: ENEST1st sub-analysis.尼罗替尼用于费城染色体阴性/BCR-ABL阳性慢性期慢性髓性白血病患者的一线治疗：ENEST1st亚组分析
J Cancer Res Clin Oncol. 2017 Jul;143(7):1225-1233. doi: 10.1007/s00432-017-2359-9. Epub 2017 Feb 21.
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4
Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis.尽管在急变期重排的bcr/c-abl序列缺失，但慢性粒细胞白血病仍持续存在。
J Exp Med. 1986 Nov 1;164(5):1389-96. doi: 10.1084/jem.164.5.1389.
5
Molecular analysis of Philadelphia chromosome positive leukaemias.费城染色体阳性白血病的分子分析
Br J Cancer Suppl. 1988 Dec;9:58-61.
6
Complex translocations, simple variant translocations and Ph-negative cases in chronic myelogenous leukaemia.
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本文引用的文献

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Chromosomes and cancer: new nomenclature and future directions.染色体与癌症：新命名法及未来方向
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2
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia.在慢性粒细胞白血病中，一种细胞癌基因易位至费城染色体。
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Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.c - ab1癌基因的易位与慢性粒细胞白血病中费城染色体的存在相关。
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5
Is the chromosomal region 9q34 always involved in variants of the Ph1 translocation?染色体区域9q34是否总是参与费城染色体易位的变异？
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Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.费城染色体断点聚集在22号染色体上一个有限的区域——bcr内。
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7
An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.慢性粒细胞白血病中的一种8千碱基abl RNA转录本。
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8
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.信件：通过喹吖因荧光和吉姆萨染色鉴定出慢性粒细胞白血病中一种新的一致染色体异常。
Nature. 1973 Jun 1;243(5405):290-3. doi: 10.1038/243290a0.
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DNA content and DNA-based centromeric index of the 24 human chromosomes.24条人类染色体的DNA含量及基于DNA的着丝粒指数
Science. 1973 Mar 16;179(4078):1126-9. doi: 10.1126/science.179.4078.1126.
10
Philadelphia chromosome-negative chronic myelogenous leukaemia: a morphological reassessment.费城染色体阴性慢性粒细胞白血病：形态学重新评估
Br J Haematol. 1985 Jul;60(3):457-67. doi: 10.1111/j.1365-2141.1985.tb07443.x.

慢性粒细胞白血病中bcr重排但c-abl未并列。

bcr Rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia.

作者信息

Bartram C R

出版信息

J Exp Med. 1985 Dec 1;162(6):2175-9. doi: 10.1084/jem.162.6.2175.

DOI:10.1084/jem.162.6.2175
PMID:2415665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187996/
Abstract

Southern blot analysis detected a bcr gene rearrangement within leukemic cells of a Philadelphia chromosome-negative chronic myelocytic leukemia (CML) patient that led to transcription of a novel 7.3 kb bcr RNA species. Participation of the c-abl oncogene in this genomic recombination could be ruled out by in situ hybridization studies and Northern blot analysis.

摘要

Southern印迹分析在一名费城染色体阴性慢性粒细胞白血病（CML）患者的白血病细胞中检测到bcr基因重排，该重排导致一种新的7.3 kb bcr RNA物种转录。原位杂交研究和Northern印迹分析排除了c-abl癌基因参与这种基因组重组的可能性。