慢性粒细胞白血病中bcr重排但c-abl未并列。
bcr Rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia.
作者信息
Bartram C R
出版信息
J Exp Med. 1985 Dec 1;162(6):2175-9. doi: 10.1084/jem.162.6.2175.
Abstract
Southern blot analysis detected a bcr gene rearrangement within leukemic cells of a Philadelphia chromosome-negative chronic myelocytic leukemia (CML) patient that led to transcription of a novel 7.3 kb bcr RNA species. Participation of the c-abl oncogene in this genomic recombination could be ruled out by in situ hybridization studies and Northern blot analysis.
摘要
Southern印迹分析在一名费城染色体阴性慢性粒细胞白血病（CML）患者的白血病细胞中检测到bcr基因重排，该重排导致一种新的7.3 kb bcr RNA物种转录。原位杂交研究和Northern印迹分析排除了c-abl癌基因参与这种基因组重组的可能性。
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