Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, PR China.
Carbohydr Res. 2013 Dec 15;382:19-24. doi: 10.1016/j.carres.2013.09.008. Epub 2013 Oct 1.
Four new phenolic glycosides, named 2-ethylene-3,5,6-trimethyl-4-phenol-1-O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside (1), 3-methoxy-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranosylpropiophenone (2), 3-hydroxy-1-(4-O-β-d-glucopyranosyl-3-methoxyphenyl)propan-1-one (3) and 4-hydroxy-3,5-bis(3'-methyl-2-butenyl)benzoic acid-O-β-d-glucopyranoside (4), were isolated from the ethanol extract of Ficus tikoua, together with six known compounds: 3,4,5-trimethoxyphenol-1-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (5), 3,4,5-trimethoxyphenol-1-O-β-d-glucopyranoside (6), 3-methoxy-4-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranosylpropiophenone (7), baihuaqianhuoside (8), 3,5-dimethoxy-4-hydroxybenzoic acid-O-β-d-glucopyranoside (9) and 2-methoxy-4-allylphenyl-1-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (10). The structures of the four new compounds were elucidated by chemical methods and MS and IR, as well as 1D and 2D NMR analyses. The cytotoxicities of the 10 compounds against HeLa, K562, HL60 and HepG2 cell lines were assessed.
从榕属植物榕乙醇提取物中分离得到了 4 个新的酚糖苷，分别命名为 2-乙烯基-3,5,6-三甲基-4-苯酚-1-O-β-d-吡喃木糖基-(1→6)-β-d-吡喃葡萄糖苷（1）、3-甲氧基-4-O-β-d-阿魏酰基-(1→2)-β-d-吡喃葡萄糖基丙基苯甲酮（2）、3-羟基-1-(4-O-β-d-吡喃葡萄糖基-3-甲氧基苯基)丙-1-酮（3）和 4-羟基-3,5-双(3'-甲基-2-丁烯基)苯甲酸-O-β-d-吡喃葡萄糖苷（4），同时还分离得到了 6 个已知化合物：3,4,5-三甲氧基苯酚-1-O-β-d-阿魏酰基-(1→6)-β-d-吡喃葡萄糖苷（5）、3,4,5-三甲氧基苯酚-1-O-β-d-吡喃葡萄糖苷（6）、3-甲氧基-4-O-β-d-阿魏酰基-(1→6)-β-d-吡喃葡萄糖基丙基苯甲酮（7）、百花前胡苷（8）、3,5-二甲氧基-4-羟基苯甲酸-O-β-d-吡喃葡萄糖苷（9）和 2-甲氧基-4-丙烯基苯-1-O-β-d-阿魏酰基-(1→6)-β-d-吡喃葡萄糖苷（10）。通过化学方法和 MS、IR 以及 1D 和 2D NMR 分析确定了这 4 个新化合物的结构。评估了这 10 种化合物对 HeLa、K562、HL60 和 HepG2 细胞系的细胞毒性。
