Mimaki Y, Kuroda M, Fukasawa T, Sashida Y
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan.
J Nat Prod. 1999 Jan;62(1):194-7. doi: 10.1021/np980346b.
Phytochemical analysis of the fresh bulbs of Allium jesdianum yielded four steroidal glycosides, (22S)-cholest-5-ene-1beta,3beta, 16beta,22-tetrol 1,16-di-O-beta-D-glucopyranoside (1), (22S)-cholest-5-ene-1beta,3beta,16beta,22-tetrol 1-O-alpha-L-rhamnopyranosyl 16-O-beta-D-glucopyranoside (2), (25R)-5alpha-spirostane-2alpha,3beta-diol 3-O-[O-beta-D-glucopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)] -O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside] (F-gitonin) (3), and (25R)-5alpha-spirostane-2alpha,3beta, 6alpha-triol 3-O-[O-beta-D-glucopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)] -O-beta-D-glucopyranosyl-(1-->4)-beta-D-galactopyranoside] (4). Compound 2 is a new natural product, and 4 is a new spirostanol saponin. Compound 3 was found to exhibit cytostatic and cytotoxic activities against several malignant tumor cells.
对紫斑蒜新鲜鳞茎进行植物化学分析，得到了四种甾体糖苷，即(22S)-胆甾-5-烯-1β,3β,16β,22-四醇1,16-二-O-β-D-吡喃葡萄糖苷(1)、(22S)-胆甾-5-烯-1β,3β,16β,22-四醇1-O-α-L-鼠李吡喃糖基16-O-β-D-吡喃葡萄糖苷(2)、(25R)-5α-螺旋甾烷-2α,3β-二醇3-O-O-β-D-吡喃葡萄糖基-(1→2)-O-[β-D-木糖吡喃糖基-(1→3)]-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷(3)和(25R)-5α-螺旋甾烷-2α,3β,6α-三醇3-O-O-β-D-吡喃葡萄糖基-(1→2)-O-[β-D-木糖吡喃糖基-(1→3)]-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷。化合物2是一种新的天然产物，化合物4是一种新的螺旋甾烷醇皂苷。发现化合物3对几种恶性肿瘤细胞具有细胞生长抑制和细胞毒活性。
