Shikimi T
Jpn J Pharmacol. 1985 Sep;39(1):83-9. doi: 10.1254/jjp.39.83.
Dextran sulfate has an action on aprotinin activity similar to that seen with heparin: preincubation of dextran sulfate with aprotinin enhanced the inhibitory effect of aprotinin on the esterolytic activity of trypsin, but did not change the effect on the proteolytic activity of trypsin or on the esterolytic and proteolytic activities of chymotrypsin. The enhancing effects of heparin and dextran sulfate were not due to increase in the active form of aprotinin which reacts with trypsin, but rather due to a change in the aprotinin molecule which would lead to an increase in aprotinin activity.
硫酸葡聚糖与抑肽酶预孵育可增强抑肽酶对胰蛋白酶酯解活性的抑制作用，但不改变其对胰蛋白酶蛋白水解活性或对糜蛋白酶酯解和蛋白水解活性的影响。肝素和硫酸葡聚糖的增强作用并非由于与胰蛋白酶反应的抑肽酶活性形式增加，而是由于抑肽酶分子的变化导致抑肽酶活性增加。
