State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People's Republic of China.
Nanotechnology. 2013 Nov 22;24(46):465603. doi: 10.1088/0957-4484/24/46/465603. Epub 2013 Oct 24.
Putting metals into organic compounds such as peptides can lead to many new desirable properties. Here we designed a novel bioorganometallic molecule, ferrocene-diphenylalanine (Fc-FF), and investigated its self-assembly behavior. We directly observed a morphological transition from metastable nanospheres to nanofibers, which led to the formation of a self-supporting hydrogel. The strong hydrophobic interaction of the Fc moiety was suggested to have a key role in this kinetically controlled self-assembly process. Moreover, the redox center of the ferrocene group further allowed us to reversibly control the self-assembly behavior of Fc-FF by altering its redox state.
将金属放入肽等有机化合物中可以产生许多新的理想性质。在这里，我们设计了一种新型的生物金属有机分子，二茂铁-苯丙氨酸（Fc-FF），并研究了它的自组装行为。我们直接观察到了从亚稳纳米球到纳米纤维的形态转变，从而形成了自支撑水凝胶。Fc 部分的强疏水力被认为在这个动力学控制的自组装过程中起着关键作用。此外，二茂铁基团的氧化还原中心进一步允许我们通过改变其氧化还原状态来可逆地控制 Fc-FF 的自组装行为。
