基于二茂铁-苯丙氨酸@氧化石墨烯杂化水凝胶的多巴胺检测。
Self-Assembly of Ferrocene-Phenylalanine@Graphene Oxide Hybrid Hydrogels for Dopamine Detection.
机构信息
State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, P. R. China.
Tianjin Key Laboratory of Membrane Science, and Desalination Technology, Tianjin University, Tianjin, 300072, P. R. China.
出版信息
Chempluschem. 2020 Oct;85(10):2341-2348. doi: 10.1002/cplu.202000579.
The effect of graphene oxide (GO) is explored on the self-assembly behavior of ferrocene-L-phenylalanine (Fc-F) in solution. The assembly behavior of Fc-F in GO dispersions at different concentrations and pH values was systematically investigated. At pH 8, a stable hybrid material could be formed by facile and elaborate supramolecular assembly. Moreover, the concentration of GO could also be used to adjust the mechanical strength of the hybrid hydrogel. Increasing the concentration of GO in the assembly process, a hydrogel with better mechanical strength could be obtained. The storage modulus could be up to 6.3 kPa by increasing the GO concentration to 1 mg/mL. Finally, the dopamine concentration in the solution could be detected in a high accuracy by loading the hybrid hydrogel onto the electrode surface. The R of linear fitting equation could reach 0.9915 in the range of 10-200 μmol/L, indicating that it has the potential as biosensing electrode material.
氧化石墨烯（GO）对二茂铁-L-苯丙氨酸（Fc-F）在溶液中的自组装行为的影响进行了探索。系统研究了 Fc-F 在不同浓度和 pH 值的 GO 分散体中的组装行为。在 pH 值为 8 时，通过简单而巧妙的超分子组装可以形成稳定的杂化材料。此外，GO 的浓度也可以用来调节杂化水凝胶的机械强度。在组装过程中增加 GO 的浓度，可以得到机械强度更好的水凝胶。通过将 GO 浓度增加到 1mg/mL，储能模量可高达 6.3kPa。最后，通过将杂化水凝胶负载到电极表面，可以以较高的精度检测溶液中的多巴胺浓度。在 10-200μmol/L 范围内，线性拟合方程的 R 可达 0.9915，表明其具有作为生物传感电极材料的潜力。
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