From the *NHI Dispute Mediation Committee, Ministry of Health and Welfare; Institute of Health and Welfare Policy, National Yang-Ming University; Department of Nursing, Kang-Ning Junior College of Medical Care and Management, Taipei, Taiwan; †College of Nursing, Taipei Medical University; New Taipei City Hospital; Oriental Institute of Technology, Taipei, Taiwan; ‡New Taipei City Hospital; Taipei Medical University, Taipei, Taiwan; Department of HealthCare Management, Yuanpei University, Hsinchu, Taiwan; §Faculty of Public Health, School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan; ∥Cheng Hsin General Hospital; Faculty of Public Health, School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan.
J Investig Med. 2014 Jan;62(1):88-96. doi: 10.2310/JIM.0000000000000018.
To discuss the prevalence and associated factors related to an elevated serum alanine aminotransferase (ALT) level among the elderly agricultural and fishing population.
A total of 6542 (3989 males and 2553 females) healthy adults voluntarily admitted to a teaching hospital for a physical checkup in 2010 in Taipei, Taiwan. Fasting blood samples were drawn via venipuncture, and clinical nurses interviewed the study participants using a structured questionnaire from.
The overall prevalence of an elevated serum ALT level was 18.2% and revealed a statistically significant decrease with increasing age (P < 0.001). The men exhibited a higher prevalence than the women (19.7% vs 15.9%; P < 0.001). Male sex; younger age; and presence of obesity, hypertension, hyperuricemia, and hypoalbuminemia were significantly associated with an elevated serum ALT level. Sex-related differences were also revealed. For the men, type 2 diabetes (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.02-1.57), hypercholesterolemia (OR, 1.78; 95% CI, 1.22-2.83), hypertriglyceridemia (OR, 1.32; 95% CI, 1.04-1.73), and low high-density lipoprotein (OR, 1.26; 95% CI, 1.05-1.51) were significantly related to an elevated serum ALT level, but this was not so for the women. The disparity of ALT in age groups was revealed.
Several sex-related differences were indicated pertaining to the prevalence of an elevated serum ALT level among elderly specific occupational population.
探讨老年农业和渔业人群血清丙氨酸氨基转移酶（ALT）水平升高的流行情况及相关因素。
2010 年，台湾台北市一家教学医院共招募了 6542 名（3989 名男性和 2553 名女性）自愿接受体检的健康成年人。通过静脉穿刺采集空腹血样，临床护士使用结构化问卷对研究参与者进行访谈。
总体上，血清 ALT 水平升高的患病率为 18.2%，且随年龄增长呈统计学显著下降（P<0.001）。男性的患病率高于女性（19.7%比 15.9%；P<0.001）。男性；年龄较小；肥胖、高血压、高尿酸血症和低白蛋白血症的存在与血清 ALT 水平升高显著相关。还揭示了性别相关差异。对于男性，2 型糖尿病（比值比[OR]，1.23；95%置信区间[CI]，1.02-1.57）、高胆固醇血症（OR，1.78；95%CI，1.22-2.83）、高三酰甘油血症（OR，1.32；95%CI，1.04-1.73）和低高密度脂蛋白（OR，1.26；95%CI，1.05-1.51）与血清 ALT 水平升高显著相关，但女性则不然。还揭示了年龄组之间 ALT 的差异。
对于特定职业的老年人群，ALT 水平升高的流行情况存在一些与性别相关的差异。
