Sussman E S, Chen S, Sussman-Fort J, Dinces E
Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA,
Brain Topogr. 2014 Jul;27(4):553-64. doi: 10.1007/s10548-013-0326-6. Epub 2013 Oct 25.
The goal of this review article is to redefine what the mismatch negativity (MMN) component of event-related potentials reflects in auditory scene analysis, and to provide an overview of how the MMN serves as a valuable tool in Cognitive Neuroscience research. In doing so, some of the old beliefs (five common 'myths') about MMN will be dispelled, such as the notion that MMN is a simple feature discriminator and that attention itself modulates MMN elicitation. A revised description of what MMN truly reflects will be provided, which includes a principal focus onto the highly context-dependent nature of MMN elicitation and new terminology to discuss MMN and attention. This revised framework will help clarify what has been a long line of seemingly contradictory results from studies in which behavioral ability to hear differences between sounds and passive elicitation of MMN have been inconsistent. Understanding what MMN is will also benefit clinical research efforts by providing a new picture of how to design appropriate paradigms suited to various clinical populations.
这篇综述文章的目的是重新定义事件相关电位的失配负波（MMN）成分在听觉场景分析中所反映的内容，并概述MMN如何作为认知神经科学研究中的一种有价值的工具。在此过程中，一些关于MMN的旧有观念（五个常见的“误区”）将被消除，比如认为MMN是一个简单的特征辨别器以及注意力本身会调节MMN诱发的观念。将提供对MMN真正反映内容的修订描述，其中包括对MMN诱发高度依赖上下文的性质的主要关注以及用于讨论MMN和注意力的新术语。这个修订后的框架将有助于澄清长期以来一系列看似矛盾的研究结果，在这些研究中，辨别声音差异的行为能力与MMN的被动诱发并不一致。理解MMN是什么也将有助于临床研究工作，通过提供一幅关于如何设计适合各种临床人群的适当范式的新图景。
