Yun Haesun, Lee Hyeok-Jin, Yoon Youngsil, Kim Kisang, Kim Sungsoo, Shin Myung-Hee, Taniguchi Miyuki, Kim Soo Ryang, Kim Mi Kyung
Division of Enteric and Hepatitis Viruses, Korea National Institute of Health, Osong, Korea.
Osong Public Health Res Perspect. 2012 Mar;3(1):31-5. doi: 10.1016/j.phrp.2012.01.005.
The epidemiological patterns of endemic hepatitis A virus (HAV) are unclear in northeastern Asia depending on the ethnicity of the country in question. The purpose of this study was to investigate the seroprevalence of HAV in northeastern China, South Korea, and Japan.
A total of 1,500 serum samples were collected from five groups of inhabitants (300 each) who were over 40 years of age (Korean Chinese, indigenous Chinese, South Korean, Korean living in Japan, and indigenous Japanese). The samples were screened for antibodies to HAV using an enzyme-linked immunosorbent assay.
Positivity for HAV antibodies was 93.7% (95% confidence interval [CI]: 90.9-96.4) in Koreans living in northeastern China, 99.7% (95% CI: 99.0-100.3) in indigenous Chinese, 98.0% (95% CI: 96.4-99.6) in indigenous Koreans, 33.3% (95% CI: 28.0-38.7) in Koreans living in Japan, and 20.4% (95% CI: 15.8-25.0) in indigenous Japanese persons. The overall anti-HAV prevalence was not significantly different between northeastern China and South Korea, but it was different in Japan.
These results indicate that differences in seroprevalence can be attributed to geological, environmental, and socioeconomic conditions rather than ethnicity.
在亚洲东北部，取决于相关国家的种族，甲型肝炎病毒（HAV）的流行模式尚不清楚。本研究的目的是调查中国东北、韩国和日本甲型肝炎病毒的血清流行率。
从五组40岁以上居民（每组300人）中收集了1500份血清样本（朝鲜族中国人、中国本土人、韩国人、居住在日本的韩国人、日本本土人）。使用酶联免疫吸附试验对样本进行甲型肝炎病毒抗体筛查。
居住在中国东北的韩国人甲型肝炎病毒抗体阳性率为93.7%（95%置信区间[CI]：90.9 - 96.4），中国本土人为99.7%（95%CI：99.0 - 100.3），韩国本土人为98.0%（95%CI：96.4 - 99.6），居住在日本的韩国人为33.3%（95%CI：28.0 - 38.7），日本本土人为20.4%（95%CI：15.8 - 25.0）。中国东北和韩国的总体抗甲型肝炎病毒流行率没有显著差异，但在日本有所不同。
这些结果表明，血清流行率的差异可归因于地理、环境和社会经济条件，而非种族。
