Victor-Kobrin C, Manser T, Moran T M, Imanishi-Kari T, Gefter M, Bona C A
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7696-700. doi: 10.1073/pnas.82.22.7696.
A wide idiotype cross-reactivity was observed among six groups of monoclonal antibodies specific for arsonate and nitrophenyl haptens, hemagglutinin of PR8 and X31 influenza viruses, dextran, A48-idiotype, and a set of six monoclonal antibodies with unknown antigenic specificity. All of these antibodies are encoded by heavy-chain variable region (VH) genes belonging to the J558 VH family. This idiotypic cross-reactivity was determined by studying the binding of these antibodies to a panel of six monoclonal anti-idiotype antibodies, each one raised against a member of the six groups of monoclonal antibodies. The administration at birth of two such monoclonal anti-idiotype antibodies induced a long-lasting suppression not only of the corresponding idiotype but also of VH-related idiotypes with different antigenic specificities. These results suggest that the idiotypes encoded by VH genes that belong to the same VH gene family are interactive one with another. The possible physiological consequences of this immunochemical cross-reactivity are discussed.
在针对砷酸盐和硝基苯基半抗原、PR8和X31流感病毒血凝素、葡聚糖、A48-独特型以及一组六种抗原特异性未知的单克隆抗体的六组单克隆抗体中,观察到广泛的独特型交叉反应性。所有这些抗体均由属于J558 VH家族的重链可变区(VH)基因编码。通过研究这些抗体与一组六种单克隆抗独特型抗体的结合来确定这种独特型交叉反应性,这六种单克隆抗独特型抗体中的每一种都是针对六组单克隆抗体中的一个成员产生的。在出生时给予两种这样的单克隆抗独特型抗体不仅诱导了相应独特型的长期抑制,还诱导了具有不同抗原特异性的VH相关独特型的长期抑制。这些结果表明,属于同一VH基因家族的VH基因编码的独特型彼此之间是相互作用的。本文讨论了这种免疫化学交叉反应性可能的生理后果。