针对A/PR/8/34（H1N1）和X-31（H3N2）流感病毒的单克隆抗体之间的共享独特型。
Shared idiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31(H3N2) influenza viruses.
作者信息
Moran T, Liu Y C, Schulman J L, Bona C A
出版信息
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1809-12. doi: 10.1073/pnas.81.6.1809.
Abstract
A monoclonal antibody specific for the hemagglutinin (HA) of influenza A X-31 (H3N2) virus (X-31) was obtained during a fusion of spleen cells from a BALB/c mouse immunized with influenza A/PR/8/34 (H1N1) virus (PR8). This monoclonal antibody (Py206) shares crossreactive idiotopes expressed on several monoclonal antibodies specific for PR8 HA and X-31 HA as well as an individual idiotope shared with one monoclonal antibody specific for X-31 HA. The presence of shared idiotypy among antibodies of such diverse binding specificities may result from regulation by idiotype-specific T cells. In addition, the results suggest that, in contrast to the diversity of paratypes expressed, relatively few germ-line variable region genes may be used in the antibody response to influenza A virus antigens.
摘要
在用甲型/PR/8/34（H1N1）病毒（PR8）免疫的BALB/c小鼠的脾细胞融合过程中，获得了一种针对甲型X-31（H3N2）流感病毒（X-31）血凝素（HA）的单克隆抗体。这种单克隆抗体（Py206）与几种针对PR8 HA和X-31 HA的单克隆抗体所表达的交叉反应独特型表位相同，并且与一种针对X-31 HA的单克隆抗体共有一个独特型表位。如此多样的结合特异性的抗体之间存在共同独特型，可能是由独特型特异性T细胞调控所致。此外，结果表明，与所表达的互补决定区的多样性相反，在针对甲型流感病毒抗原的抗体应答中可能使用相对较少的种系可变区基因。
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