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使用口服避孕药的女性的血脂情况。

Lipid profile of women using oral contraceptive pills.

作者信息

Naz F, Jyoti S, Akhtar N, Afzal M, Siddique Y H

机构信息

Human Genetics and Toxicology Laboratory, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh-202002 (U.P), India.

出版信息

Pak J Biol Sci. 2012 Oct 1;15(19):947-50. doi: 10.3923/pjbs.2012.947.950.

Abstract

Oral contraceptives (OCs) are the most popular type of birth control pills. The study was designed to examine the biochemical changes which occur due to the use of oral contraceptive pills (OCs). The study was based on the questionnaire for having the information of any reproductive history fasting, age, health, nature of menstrual cycle, bleeding, disease etc and blood profiling for biochemical analysis of the women includes high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and triglycerides (TG). Lipid profiling was carried out by using a commercially available diagnostic test kits. SPSS was used to analyze the data. The results showed statistically significant differences among users of OCs compared to non-users. Total cholesterol (242.92 +/- 2.842 mg dL(-1)), HDL-C (58.65 +/- 1.098 mg dL(-1)), LDL-C (115.84 +/- 1.266 mg dL(-1)) and triglycerides (105.56 +/- 2.341 mg dL(-1)) were significantly higher compared to the non-users (Total cholesterol 218.49 +/- 1.762, HDL-C 48.17 +/- 0.543, LDL-C 100.321 +/- 0.951 and triglycerides 83.77 +/- 2.299 mg dL(-1)). The result suggests that OCs increase the level of high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and triglycerides (TG).

摘要

口服避孕药(OCs)是最受欢迎的一类避孕药。该研究旨在检查因使用口服避孕药(OCs)而发生的生化变化。该研究基于一份问卷,以获取任何生殖史、空腹情况、年龄、健康状况、月经周期性质、出血情况、疾病等信息,并对女性进行血液分析以进行生化分析,包括高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)和甘油三酯(TG)。使用市售诊断试剂盒进行血脂分析。采用SPSS分析数据。结果显示,与未使用者相比,口服避孕药使用者之间存在统计学上的显著差异。与未使用者(总胆固醇218.49±1.762、HDL-C 48.17±0.543、LDL-C 100.321±0.951和甘油三酯83.77±2.299mg/dL)相比,总胆固醇(242.92±2.842mg/dL)、HDL-C(58.65±1.098mg/dL)、LDL-C(115.84±1.266mg/dL)和甘油三酯(105.56±2.341mg/dL)显著更高。结果表明,口服避孕药会增加高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)和甘油三酯(TG)的水平。

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