口服避孕药与血脂谱的关系：来自霍韦扎赫队列研究（HCS）的结果。
Association between oral contraceptives with lipid profile: results from Hoveyzeh cohort study (HCS).
机构信息
Alimentary Tract Research Center, Department of Internal Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
出版信息
BMC Womens Health. 2023 Oct 24;23(1):552. doi: 10.1186/s12905-023-02703-7.
BACKGROUND
Oral contraceptives (OCs) affect lipid metabolism, which can cause hyperlipidemia, a risk factor for cardiovascular diseases. The study was designed to evaluate the possible changes in lipid profile due to using OCs.
METHODS
A cross-sectional study was conducted from April 2016 to August 2018 among women from the baseline phase Hoveyzeh cohort study (HCS). Sociodemographic data, anthropometric measurements, physical activity, and biochemical blood tests were measured for every participant. Multiple logistic regression was used to adjust the potential confounders.
RESULTS
Among 2272 participants, 1549 women were OC users, and 723 women were non-user OCs. The mean lipid profile levels were higher in OC users than in non-user OCs. Odds of abnormal Total cholesterol (TC) in OC users were significantly higher than those of non-users OCs [OR = 1.29 (95% CI;1.05 to 1.58)]. Also, the Odds of abnormal low-density lipoprotein (LDL) in OC users was 12% higher than in non-user OCs. However, no significant relationship between abnormal LDL with Oral Contraceptive Pills (OCPs) was observed.
CONCLUSIONS
The mean lipid profile was higher in OC users compared to non-user OCs. This finding highlights the need for public health strategies to prevent and detect hyperlipidemia in user OCs.
背景
口服避孕药（OCs）会影响脂代谢，从而导致高血脂，这是心血管疾病的一个风险因素。本研究旨在评估使用 OCs 可能导致的血脂谱变化。
方法
2016 年 4 月至 2018 年 8 月，在 Hoveyzeh 队列研究（HCS）的基线阶段，对来自女性的进行了一项横断面研究。对每位参与者进行了社会人口统计学数据、人体测量学测量、身体活动和生化血液检查。使用多因素逻辑回归来调整潜在的混杂因素。
结果
在 2272 名参与者中，有 1549 名女性为 OC 用户，723 名女性为非 OC 用户。OC 用户的平均血脂谱水平高于非 OC 用户。OC 用户异常总胆固醇（TC）的几率明显高于非使用者 OC [OR=1.29（95%CI；1.05 至 1.58）]。此外，OC 用户异常低密度脂蛋白（LDL）的几率比非使用者 OC 高 12%。然而，未观察到异常 LDL 与口服避孕药（OCPs）之间存在显著关系。
结论
与非 OC 用户相比，OC 用户的平均血脂谱水平更高。这一发现强调了需要采取公共卫生策略来预防和检测 OC 用户的高血脂。
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