Rasmi Yousef, Zeynalzadeh Javad, Shirpoor Alireza, Seyedmohammadzad Mirhossein, Hajhosseini Reza
Professor, Cellular and Molecular Research Center, Urmia University of Medical Sciences , Urmia, Iran; Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran .
Student, Department of Biology, Faculty of Sciences, Payam-e Noor University , Tehran, Iran .
J Clin Diagn Res. 2016 Jul;10(7):BC07-9. doi: 10.7860/JCDR/2016/18048.8185. Epub 2016 Jul 1.
Chronic inflammation caused by Helicobacter pylori (H.pylori) infection has a pathogenic role in Cardiac Syndrome X (CSX). In addition, it has shown that bacterial infection may affect blood lipids.
To assess if H.pylori affects the level of lipid profile in CSX.
Eighty-eight CSX patients and 97 healthy controls were enrolled. The Total Cholesterol (TC), Triglyceride (TG), Lipoprotein A (LP{A}), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Apoprotein A1 (APOA1), and Apoprotein B (APOB) was estimated colorimetrically. In addition, the presence of IgG antibody to H.pylori was tested in plasma samples by using enzyme linked immunosorbent assay method.
TC, LP{A}, LDL, APOA1 and APOB levels in CSX group were significantly higher than those of the control group (p<0.05). But, these parameters in H.pylori positive and H.pylori negative, among CSX and control groups were not significant.
Increased plasma level of lipid profile and H.pylori infection were associated with CSX; it seems that plasma lipid disorders have a significant role in the development of CSX.
幽门螺杆菌（H.pylori）感染引起的慢性炎症在心脏X综合征（CSX）中具有致病作用。此外，研究表明细菌感染可能会影响血脂。
评估幽门螺杆菌是否会影响CSX患者的血脂水平。
纳入88例CSX患者和97例健康对照者。采用比色法测定总胆固醇（TC）、甘油三酯（TG）、脂蛋白A（LP{A}）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、载脂蛋白A1（APOA1）和载脂蛋白B（APOB）。此外，采用酶联免疫吸附测定法检测血浆样本中幽门螺杆菌IgG抗体的存在情况。
CSX组的TC、LP{A}、LDL、APOA1和APOB水平显著高于对照组（p<0.05）。但是，在CSX组和对照组中，幽门螺杆菌阳性和阴性患者的这些参数并无显著差异。
血脂水平升高与幽门螺杆菌感染均与CSX相关；血浆脂质紊乱似乎在CSX的发展中起重要作用。
