6-甲氧基乙基氨基萘莫司他洗脱磁性微球的微流体制备
Microfluidic fabrication of 6-methoxyethylamino numonafide-eluting magnetic microspheres.
作者信息
Kim D-H, Choy T, Huang S, Green R M, Omary R A, Larson A C
机构信息
Department of Radiology, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA.
Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
出版信息
Acta Biomater. 2014 Feb;10(2):742-50. doi: 10.1016/j.actbio.2013.10.018. Epub 2013 Oct 23.
Recently, 6-methoxyethylamino numonafide (MEAN) exhibited potent inhibition of hepatocellular carcinoma (HCC) cell growth and less systemic toxicity than amonafide. MEAN may serve as an ideal candidate for the treatment of HCC; however, liver-directed, selective infusion methods may be critical to maximize the MEAN dose delivered to the targeted tumors. This study describes the microfluidic fabrication of MEAN-eluting ultrasmall superparamagnetic iron oxide (USPIO) nanocluster-containing alginate microspheres (MEAN-magnetic microspheres) intended for selective transcatheter delivery to HCC. The resulting drug delivery platform was mono-disperse, microsphere sizes were readily controlled based on channel flow rates during synthesis procedures, and drug release rates from the microspheres could be readily controlled with the introduction of USPIO nanoclusters. The MR relaxivity properties of the microspheres suggest the feasibility of in vivo imaging after administration, and these microspheres exhibited potent therapeutic effects significantly inhibiting cell growth inducing apoptosis in hepatoma cells.
最近，6-甲氧基乙基氨基萘莫司他（MEAN）对肝癌（HCC）细胞生长表现出强效抑制作用，且与氨萘非相比全身毒性更小。MEAN可能是治疗肝癌的理想候选药物；然而，肝脏靶向的选择性输注方法对于最大化输送到靶向肿瘤的MEAN剂量可能至关重要。本研究描述了用于经导管选择性递送至肝癌的含MEAN洗脱超小超顺磁性氧化铁（USPIO）纳米簇的海藻酸盐微球（MEAN磁性微球）的微流体制备。所得药物递送平台是单分散的，微球尺寸在合成过程中可根据通道流速轻松控制，并且通过引入USPIO纳米簇可轻松控制微球的药物释放速率。微球的磁共振弛豫特性表明给药后体内成像的可行性，并且这些微球表现出显著的治疗效果，可显著抑制肝癌细胞生长并诱导其凋亡。
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