Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
Biomater Sci. 2017 Dec 19;6(1):79-90. doi: 10.1039/c7bm00872d.
Photodynamic therapy (PDT) based upon the use of light and photosensitizers (PSs) has been used as a novel treatment approach for a variety of tumors. It, however, has several major limitations in the clinic: poor water solubility, long-term phototoxicity, low tumor targeting efficacy, and limited light penetration. With advances in nanotechnology, materials science, and clinical interventional imaging procedures, various smart-PSs have been developed for improving their cancer-therapeutic efficacy while reducing the adverse effects. Here, we briefly review state-of-the-art smart-PSs and discuss the future directions of PDT technology.
基于光和光敏剂 (PSs) 的光动力疗法 (PDT) 已被用作多种肿瘤的新型治疗方法。然而，它在临床上存在几个主要限制：水溶性差、长期光毒性、低肿瘤靶向效率和有限的光穿透性。随着纳米技术、材料科学和临床介入成像程序的进步，已经开发出各种智能 PSs 来提高其癌症治疗效果，同时减少不良反应。在这里，我们简要回顾了最先进的智能 PSs，并讨论了 PDT 技术的未来方向。
