Department of Nursing, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road Sec.1, Taipei 10051, Taiwan.
Psychosom Med. 2013 Nov-Dec;75(9):807-14. doi: 10.1097/PSY.0000000000000014. Epub 2013 Oct 25.
Metabolic syndrome (MetS) is reportedly associated with mental disorders that are known to increase the risk of suicide. However, it is not known whether this association is independent of other risk indicators of suicide. This study therefore investigated whether metabolic abnormalities increase the risk of suicide during a 10-year follow-up period.
This prospective study enrolled participants from a community-based integrated screening samples cohort in Taiwan. Of the 76,297 people recruited for this study, 12,094 had MetS at baseline. The independent variables were MetS and its components such as high blood pressure and high blood lipid levels. The outcome was death from suicide (n = 146).
MetS was associated with an increased risk of suicide risk by 16% per MetS component (95% confidence interval [CI] = 1%-33%), adjusting for demographics, life-style factors, and clinical correlates. Of the five MetS components, elevated blood pressure was independently associated with suicide-related mortality (adjusted hazard ratio [aHR] = 1.49, 95% CI = 1.03-2.15).
This analysis of community-based longitudinal data showed that MetS and its components, particularly elevated blood pressure, correlated positively with suicide risk after controlling other factors. Therefore, public mental health interventions targeting suicide reduction may need to specifically focus on individuals with hypertension and other components of the MetS.
据报道，代谢综合征（MetS）与精神障碍有关，而精神障碍已知会增加自杀的风险。然而，目前尚不清楚这种关联是否独立于其他自杀风险指标。因此，本研究旨在调查代谢异常是否会在 10 年的随访期间增加自杀风险。
本前瞻性研究纳入了来自台湾社区为基础的综合筛查样本队列的参与者。在这项研究中，共招募了 76297 人，其中 12094 人在基线时有 MetS。自变量是 MetS 及其组成部分，如高血压和高血脂水平。因变量是自杀死亡（n=146）。
在调整了人口统计学、生活方式因素和临床相关因素后，每增加一个 MetS 组成部分，自杀风险增加 16%（95%置信区间 [CI] = 1%-33%）。在五个 MetS 组成部分中，高血压与自杀相关死亡率独立相关（调整后的危险比[aHR] = 1.49，95% CI = 1.03-2.15）。
本社区纵向数据分析显示，在控制了其他因素后，MetS 及其组成部分，特别是高血压，与自杀风险呈正相关。因此，针对减少自杀的公众心理健康干预措施可能需要特别关注高血压和 MetS 其他组成部分的个体。
