Department of Oncology Surgery, Fuzhou Hospital of Traditional Chinese Medicine Affiliated to Fujian University of Traditional Chinese Medicine, No.102 Gudong Road, Gulou District, Fuzhou City, 350001, Fujian Province, China.
Department of Physiology, College of Medicine, Chosun University, Gwangju, Republic of Korea.
BMC Psychiatry. 2024 Sep 30;24(1):641. doi: 10.1186/s12888-024-06107-1.
Few studies have explored the correlation between overactive bladder (OAB) and suicidal ideation. This study aims to investigate the association between OAB and suicidal ideation, as well as the relationship between OAB and all-cause mortality among individuals with suicidal ideation.
Data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES) were analyzed using cross-sectional and cohort study designs. Weighted multivariable logistic regression models were used to examine the association between OAB and suicidal ideation. Kaplan-Meier curves and weighted multivariable Cox proportional hazards models assessed the relationship between OAB and all-cause mortality among those with suicidal ideation. Interaction analyses on subgroups were conducted to validate the findings. Mediation analysis was performed to examine the effect of depression on the relationship between OAB and suicidal ideation.
Among 33,426 participants aged ≥ 20 years, 1,290 (3.8%) reported suicidal ideation. After adjusting for potential confounders, participants with OAB were 2.57 times more likely to have suicidal ideation (P < 0.001). Over an average follow-up of 87 months, 197 participants with suicidal ideation died. The Cox model revealed that participants with OAB had a 3.08 times higher risk of death (P = 0.006). Kaplan-Meier curves indicated higher survival rates for non-OAB participants. Mediation analysis indicates that depression significantly mediates the relationship between OAB and suicidal ideation, with a mediation proportion of 75.25% (P < 0.001).
OAB is positively associated with the incidence of suicidal ideation and all-cause mortality among participants with suicidal ideation. Additionally, the association between OAB and suicidal ideation is mediated by depression.
很少有研究探讨过膀胱过度活动症（OAB）与自杀意念之间的相关性。本研究旨在调查 OAB 与自杀意念之间的关联，以及 OAB 与有自杀意念个体的全因死亡率之间的关系。
使用横断面和队列研究设计对 2005-2018 年全国健康和营养调查（NHANES）的数据进行了分析。使用加权多变量逻辑回归模型来检验 OAB 与自杀意念之间的关联。Kaplan-Meier 曲线和加权多变量 Cox 比例风险模型评估了在有自杀意念的个体中 OAB 与全因死亡率之间的关系。进行了亚组交互分析以验证研究结果。进行了中介分析以检验抑郁对 OAB 与自杀意念之间关系的影响。
在 33426 名年龄≥20 岁的参与者中，有 1290 人（3.8%）报告有自杀意念。在调整了潜在混杂因素后，患有 OAB 的参与者发生自杀意念的可能性是未患 OAB 参与者的 2.57 倍（P<0.001）。在平均 87 个月的随访期间，有 197 名有自杀意念的参与者死亡。Cox 模型显示，患有 OAB 的参与者死亡风险增加了 3.08 倍（P=0.006）。Kaplan-Meier 曲线表明，非 OAB 参与者的生存率更高。中介分析表明，抑郁显著中介了 OAB 与自杀意念之间的关系，中介比例为 75.25%（P<0.001）。
OAB 与有自杀意念个体的自杀意念发生率和全因死亡率呈正相关。此外，OAB 与自杀意念之间的关联是由抑郁介导的。
