Agarwal Nidheesh, Mittal Asit, Kuldeep Cm, Gupta Lalit Kumar, Khare Ashok Kumar, Mehta Sharad
Department of Dermatology, RNT Medical College, Udaipur, Rajasthan, India.
J Cutan Aesthet Surg. 2013 Jul;6(3):144-7. doi: 10.4103/0974-2077.118408.
Chickenpox (varicella) is a common viral disease caused by Varicella zoster virus. Facial atrophic scars after varicella infection are not uncommon and pose a cosmetic problem. Like atrophic scars of other aetiologies, they are a difficult condition to treat. There are not enough references in the literature regarding efficient treatment of post varicella scars. High strength Trichloroacetic acid (TCA), which is known to cause dermal collagen remodelling, was used to treat varicella scars in the present study.
The study was undertaken to assess the efficiency of Chemical Reconstruction of Skin Scars (CROSS) technique using 100% TCA in the treatment of atrophic facial post varicella scars.
Open label, pilot study.
A total of 16 patients with atrophic facial post varicella scars were treated by focal application of 100% TCA solution by pressing down upon the scar surface by a toothpick (CROSS technique). Total 4 sittings were given at 2 weekly intervals and the results evaluated after 3 months of follow-up. Statistical analysis was carried out using Fischer's exact t-test.
All of the 13 patients who completed the study showed good clinical improvement, with 69% patients grading the response as excellent (>75%) improvement, whereas the rest 31% patients reporting good (51-75%) improvement. No significant complications were seen in any patient.
CROSS technique using 100% TCA is a safe, cheap and effective therapy for the treatment of post varicella scars.
水痘是由水痘带状疱疹病毒引起的一种常见病毒性疾病。水痘感染后出现面部萎缩性瘢痕并不少见，且会造成美容问题。与其他病因导致的萎缩性瘢痕一样，它们是一种难以治疗的病症。关于水痘后瘢痕的有效治疗，文献中的参考资料不足。已知高浓度三氯乙酸（TCA）可引起真皮胶原重塑，本研究使用其治疗水痘瘢痕。
本研究旨在评估使用100% TCA的皮肤瘢痕化学重建（CROSS）技术治疗水痘后面部萎缩性瘢痕的疗效。
开放标签的试点研究。
总共16例水痘后面部萎缩性瘢痕患者，通过用牙签按压瘢痕表面局部应用100% TCA溶液进行治疗（CROSS技术）。每隔2周进行总共4次治疗，并在随访3个月后评估结果。使用费舍尔精确t检验进行统计分析。
完成研究的13例患者均显示出良好的临床改善，69%的患者将反应评为优秀（改善>75%），其余31%的患者报告良好（改善51 - 75%）。未在任何患者中观察到明显并发症。
使用100% TCA的CROSS技术是治疗水痘后瘢痕的一种安全、廉价且有效的疗法。
