Departamento de Genética e Instituto de Biotecnología, Lab. 127, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain.
Epigenetics and Sex Development Group, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany.
Sex Dev. 2021;15(5-6):335-350. doi: 10.1159/000519237. Epub 2021 Oct 6.
Non-coding RNAs (ncRNAs) are a group of RNAs that do not encode functional proteins, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), and short interfering RNAs (siRNAs). In the last 2 decades an effort has been made to uncover the role of ncRNAs during development and disease, and nowadays it is clear that these molecules have a regulatory function in many of the developmental and physiological processes where they have been studied. In this review, we provide an overview of the role of ncRNAs during gonad determination and development, focusing mainly on mammals, although we also provide information from other species, in particular when there is not much information on the function of particular types of ncRNAs during mammalian sexual development.
非编码 RNA（ncRNA）是一组不编码功能蛋白的 RNA，包括长非编码 RNA（lncRNA）、微小 RNA（miRNA）、PIWI 相互作用 RNA（piRNA）和小干扰 RNA（siRNA）。在过去的 20 年中，人们一直在努力揭示 ncRNA 在发育和疾病中的作用，如今已经清楚的是，这些分子在它们所研究的许多发育和生理过程中具有调节功能。在这篇综述中，我们概述了 ncRNA 在性腺决定和发育过程中的作用，主要集中在哺乳动物上，尽管我们也提供了来自其他物种的信息，特别是在关于哺乳动物性发育过程中特定类型 ncRNA 的功能信息较少的情况下。
