• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TMEM106B 和 APOE 多态性相互作用，使汉族人群易患晚发性阿尔茨海默病。

TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in Han Chinese.

机构信息

Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No.5 Donghai Middle Road, Qingdao, 266071, People's Republic of China.

出版信息

J Neural Transm (Vienna). 2014;121(3):283-7. doi: 10.1007/s00702-013-1106-x. Epub 2013 Oct 29.

DOI:10.1007/s00702-013-1106-x
PMID:24166182
Abstract

Recent large genome-wide association studies have found variants in TMEM106B (top SNP rs1990622) as a strong risk factor for frontotemporal lobar degeneration. Moreover, the TMEM106B risk variant is also implicated in the pathologic presentation of Alzheimer's disease (AD). Here, we evaluated the association between TMEM106B rs1990622 polymorphism and late-onset AD (LOAD) in a Northern Han Chinese population consists of 1,133 LOAD patients and 1,159 controls. Our data demonstrate that TMEM106B and APOE interact to increase AD risk.

摘要

最近的大规模全基因组关联研究发现，TMEM106B（顶级 SNP rs1990622）中的变异是额颞叶痴呆的一个强烈危险因素。此外，TMEM106B 风险变异也与阿尔茨海默病（AD）的病理表现有关。在这里，我们在由 1133 名 LOAD 患者和 1159 名对照组成的北方汉族人群中评估了 TMEM106B rs1990622 多态性与迟发性 AD（LOAD）之间的关联。我们的数据表明，TMEM106B 和 APOE 相互作用增加 AD 风险。

相似文献

1
TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in Han Chinese.TMEM106B 和 APOE 多态性相互作用，使汉族人群易患晚发性阿尔茨海默病。
J Neural Transm (Vienna). 2014;121(3):283-7. doi: 10.1007/s00702-013-1106-x. Epub 2013 Oct 29.
2
The Association of MME microRNA Binding Site Polymorphism with the Risk of Late Onset Alzheimer's Disease in Northern Han Chinese.MME微小RNA结合位点多态性与中国北方汉族人群晚发型阿尔茨海默病风险的关联
Curr Neurovasc Res. 2017;14(2):90-95. doi: 10.2174/1567202614666170313110301.
3
rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues.rs1990622 变异与阿尔茨海默病相关，并调节人脑组织中 TMEM106B 的表达。
BMC Med. 2021 Jan 19;19(1):11. doi: 10.1186/s12916-020-01883-5.
4
Genetic association of CUGBP2 and DNMBP with Alzheimer' s disease in the Chinese Han population.CUGBP2和DNMBP与中国汉族人群阿尔茨海默病的遗传关联。
Curr Alzheimer Res. 2015;12(3):228-32. doi: 10.2174/156720501203150317151426.
5
Interleukin-23 receptor polymorphisms are associated with Alzheimer's disease in Han Chinese.白细胞介素-23 受体多态性与汉族人群阿尔茨海默病有关。
J Neuroimmunol. 2014 Jun 15;271(1-2):43-8. doi: 10.1016/j.jneuroim.2014.03.013. Epub 2014 Mar 21.
6
Gene- Gene Interaction between PPARG and APOE Gene on Late-Onset Alzheimer's Disease: A Case- Control Study in Chinese Han Population.PPARG与APOE基因在晚发型阿尔茨海默病中的基因-基因相互作用：中国汉族人群病例对照研究
J Nutr Health Aging. 2017;21(4):397-403. doi: 10.1007/s12603-016-0794-y.
7
Association between the SORL1 rs2070045 polymorphism and late-onset Alzheimer's disease: interaction with the ApoE genotype in the Chinese Han population.SORL1 rs2070045 多态性与晚发性阿尔茨海默病的关联：在中国汉族人群中与 ApoE 基因型的相互作用。
Neurosci Lett. 2014 Jan 24;559:94-8. doi: 10.1016/j.neulet.2013.11.042. Epub 2013 Dec 3.
8
TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.TMEM106B 与临床诊断患者队列的额颞叶退行性变有关。
Brain. 2011 Mar;134(Pt 3):808-15. doi: 10.1093/brain/awr007.
9
NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese.NLRP3 多态性与汉族晚发性阿尔茨海默病有关。
J Neuroimmunol. 2013 Dec 15;265(1-2):91-5. doi: 10.1016/j.jneuroim.2013.10.002. Epub 2013 Oct 10.
10
Association of DISC1 Polymorphisms with Late-Onset Alzheimer's Disease in Northern Han Chinese.DISC1 多态性与北方汉族人群晚发性阿尔茨海默病的关联。
Mol Neurobiol. 2017 May;54(4):2922-2927. doi: 10.1007/s12035-016-9881-7. Epub 2016 Mar 29.

引用本文的文献

1
Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover.NMT1/2对跨膜蛋白106B（TMEM106B）的肉豆蔻酰化修饰调节了TMEM106B的运输和周转。
J Biol Chem. 2025 May 30;301(7):110322. doi: 10.1016/j.jbc.2025.110322.
2
Physiological and pathological functions of TMEM106B in neurodegenerative diseases.TMEM106B 在神经退行性疾病中的生理和病理功能。
Cell Mol Life Sci. 2024 May 6;81(1):209. doi: 10.1007/s00018-024-05241-z.
3
Association of TMEM106B with Cortical Gene Expression in Neurodegenerative Conditions.

本文引用的文献

1
The frontotemporal lobar degeneration risk factor, TMEM106B, regulates lysosomal morphology and function.额颞叶退行性变风险因子 TMEM106B 调节溶酶体形态和功能。
Hum Mol Genet. 2013 Feb 15;22(4):685-95. doi: 10.1093/hmg/dds475. Epub 2012 Nov 6.
2
TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.TMEM106B，额颞叶痴呆的风险基因，受 microRNA-132/212 簇调控，并影响颗粒蛋白途径。
J Neurosci. 2012 Aug 15;32(33):11213-27. doi: 10.1523/JNEUROSCI.0521-12.2012.
3
TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease.
跨膜蛋白106B（TMEM106B）与神经退行性疾病中皮质基因表达的关联。
Genes (Basel). 2024 Mar 26;15(4):416. doi: 10.3390/genes15040416.
4
Assessing the impact of novel risk loci on Alzheimer's and Parkinson's diseases in a Chinese Han cohort.评估新风险基因座对中国汉族人群中阿尔茨海默病和帕金森病的影响。
Front Neurol. 2024 Jan 31;15:1326692. doi: 10.3389/fneur.2024.1326692. eCollection 2024.
5
The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus.主要的 TMEM106B 痴呆风险等位基因影响衰老人类海马体中的 TMEM106B 蛋白水平、纤维形成和髓鞘脂质动态平衡。
Mol Neurodegener. 2023 Sep 19;18(1):63. doi: 10.1186/s13024-023-00650-3.
6
The major TMEM106B dementia risk allele affects TMEM106B protein levels and myelin lipid homeostasis in the ageing human hippocampus.主要的跨膜蛋白106B（TMEM106B）痴呆风险等位基因影响衰老人类海马体中TMEM106B蛋白水平和髓磷脂脂质稳态。
Res Sq. 2023 Jan 17:rs.3.rs-2392941. doi: 10.21203/rs.3.rs-2392941/v1.
7
Acts as a Modifier of Cognitive and Motor Functions in Amyotrophic Lateral Sclerosis.在肌萎缩侧索硬化症中作为认知和运动功能的调节剂。
Int J Mol Sci. 2022 Aug 17;23(16):9276. doi: 10.3390/ijms23169276.
8
Analysis of Genetic Association Between Polymorphism and Alzheimer's Disease Risk in the Southern Chinese Population.中国南方人群中多态性与阿尔茨海默病风险的遗传关联分析。
Front Aging Neurosci. 2022 May 25;14:819499. doi: 10.3389/fnagi.2022.819499. eCollection 2022.
9
Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.额颞叶痴呆伴 tau 蛋白病理的淀粉样纤维由 TMEM106B 而非 TDP-43 组成。
Nature. 2022 May;605(7909):304-309. doi: 10.1038/s41586-022-04670-9. Epub 2022 Mar 28.
10
Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents.阿尔茨海默病：载脂蛋白E与肠道微生物群介导氧化应激的最新进展及前瞻性干预药物
Aging Dis. 2022 Feb 1;13(1):87-102. doi: 10.14336/AD.2021.0616. eCollection 2022 Feb.
跨膜蛋白106B风险变异与阿尔茨海默病的病理表现有关。
Neurology. 2012 Aug 14;79(7):717-8. doi: 10.1212/WNL.0b013e318264e3ac. Epub 2012 Aug 1.
4
Progranulin regulates neuronal outgrowth independent of sortilin.颗粒蛋白前体通过调控神经元的生长而独立于分选连接蛋白。
Mol Neurodegener. 2012 Jul 10;7:33. doi: 10.1186/1750-1326-7-33.
5
Recent insights into the involvement of progranulin in frontotemporal dementia.近期关于颗粒蛋白前体在额颞叶痴呆中作用的新认识。
Curr Neuropharmacol. 2011 Dec;9(4):632-42. doi: 10.2174/157015911798376361.
6
SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population.SORCS1 和 APOE 多态性相互作用，导致北方汉族人群晚年发病的阿尔茨海默病风险增加。
Brain Res. 2012 Apr 11;1448:111-6. doi: 10.1016/j.brainres.2012.01.067. Epub 2012 Feb 3.
7
TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype.TDP-43 病理学改变在早发性家族性和散发性阿尔茨海默病、晚发性阿尔茨海默病和唐氏综合征中的表现：与年龄、海马硬化和临床表型的关系。
Acta Neuropathol. 2011 Dec;122(6):703-13. doi: 10.1007/s00401-011-0879-y. Epub 2011 Oct 4.
8
TMEM106B a novel risk factor for frontotemporal lobar degeneration.TMEM106B 是额颞叶痴呆的一个新的风险因素。
J Mol Neurosci. 2011 Nov;45(3):516-21. doi: 10.1007/s12031-011-9555-x. Epub 2011 May 26.
9
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.阿尔茨海默病所致痴呆的诊断：美国国家老龄化研究所-阿尔茨海默病协会工作组关于阿尔茨海默病诊断指南的建议。
Alzheimers Dement. 2011 May;7(3):263-9. doi: 10.1016/j.jalz.2011.03.005. Epub 2011 Apr 21.
10
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.家族性晚发性阿尔茨海默病的全基因组关联研究复制了 BIN1 和 CLU，并在与 APOE 相互作用的情况下提名了 CUGBP2。
PLoS Genet. 2011 Feb;7(2):e1001308. doi: 10.1371/journal.pgen.1001308. Epub 2011 Feb 17.