Wells Greg D, Wilkes Donna L, Schneiderman Jane E, Thompson Sara, Coates Allan L, Ratjen Felix
Department of Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Canada; Faculty of Kinesiology, Physical Education, The University of Toronto, Toronto, Canada.
Pediatr Pulmonol. 2014 Sep;49(9):878-84. doi: 10.1002/ppul.22928. Epub 2013 Oct 25.
Although peak aerobic capacity (VO(2peak)) has been linked to outcome in patients with cystic fibrosis (CF), measuring is time consuming, and requires expensive equipment and expertise that is not readily available in all centers. Other fitness parameters such as peak anaerobic power, measures of power and strength may be simpler to deliver in the clinic. The relationship between these measures and established outcomes such as forced expiratory volume in one second (FEV(1)) and peak aerobic power (VO(2peak)) in CF remains unclear. Therefore we evaluated (a) aerobic fitness, (b) anaerobic fitness, and (c) upper and lower body muscle strength to determine their relationship to FEV(1) and VO(2peak) in children with CF.
Eighty-two patients (7-18 years) with CF (40 female) from the CF clinic at The Hospital for Sick Children in Toronto performed a maximal incremental cycling test to exhaustion. Anaerobic power (W) for 10 and 30 sec cycling trials as well as vertical jump (VJ) and hand grip strength (HG) were compared to FEV(1) and VO(2peak).
Absolute VO(2peak) (R(2) = 0.16, P < 0.001), anaerobic power (R(2) = 0.21, P < 0.001), and hand grip strength (R(2) = 0.10, P = 0.003) were significantly correlated to lung function whereas measures of explosive lower body strength (VJ) were not. Anaerobic power (R(2) = 0.16, P = 0.001) and hand grip strength (R(2) = 0.08, P = 0.01) were related to VO(2peak). Vertical jump was correlated with VO(2peak) (R(2) = 0.29, P < 0.001) but not FEV(1).
Simple fitness tests such as hand grip strength and anaerobic cycle tests may be useful indicators of lung health and fitness.
尽管峰值有氧能力（VO₂峰值）与囊性纤维化（CF）患者的预后相关，但测量过程耗时，且需要昂贵的设备以及并非所有中心都具备的专业知识。其他健康参数，如峰值无氧功率、功率和力量的测量，在临床中可能更易于实施。这些测量指标与CF患者的既定预后指标，如一秒用力呼气量（FEV₁）和峰值有氧功率（VO₂峰值）之间的关系仍不明确。因此，我们评估了（a）有氧健康状况、（b）无氧健康状况以及（c）上下肢肌肉力量，以确定它们与CF儿童FEV₁和VO₂峰值的关系。
来自多伦多病童医院CF诊所的82名CF患者（7 - 18岁，40名女性）进行了最大递增自行车测试直至力竭。将10秒和30秒自行车测试的无氧功率（瓦特）以及垂直跳跃（VJ）和握力（HG）与FEV₁和VO₂峰值进行比较。
绝对VO₂峰值（R² = 0.16，P < 0.001）、无氧功率（R² = 0.21，P < 0.001）和握力（R² = 0.10，P = 0.003）与肺功能显著相关，而爆发性下肢力量测量指标（VJ）则不然。无氧功率（R² = 0.16，P = 0.001）和握力（R² = 0.08，P = 0.01）与VO₂峰值相关。垂直跳跃与VO₂峰值相关（R² = 0.29，P < 0.001），但与FEV₁无关。
诸如握力和无氧循环测试等简单的健康测试可能是肺部健康和身体状况的有用指标。
