Lesiak Ashton D, Adams Kendra J, Domin Marek A, Henck Colin, Shepard Jason R E
Department of Chemistry, University at Albany, State University of New York (SUNY), 1400 Washington Ave, Albany, NY, 12222, USA.
Drug Test Anal. 2014 Jul-Aug;6(7-8):788-96. doi: 10.1002/dta.1540. Epub 2013 Oct 25.
Dimethylamylamine (DMAA) is a sympathomimetic amine found in weight-loss/workout supplements or used as an appetite suppressant. DMAA is a stimulant that is banned by the World Anti-Doping Agency (WADA). Adverse health effects as well as fatalities have been implicated with its use. Direct analysis in real time mass spectrometry (DART-MS) is an ambient ionization method that was employed to rapidly identify the presence of DMAA in various samples without any extraction or preparations whatsoever. DMAA was first identified in supplements, sampled directly in their solid forms. Furthermore, DMAA was detected directly in urine over 48 h as a means of indicating recent abuse of the substance. DART-MS analysis is instantaneous, and coupled with the high mass accuracy associated with the time-of-flight mass analyzer, results in unequivocal identification of the presence of DMAA. These features demonstrate DART-MS as an attractive potential alternative screening method for the presence of drugs and medications or for toxicological investigations.
二甲基戊胺（DMAA）是一种拟交感神经胺，存在于减肥/健身补充剂中或用作食欲抑制剂。DMAA是一种兴奋剂，被世界反兴奋剂机构（WADA）禁止使用。其使用已涉及不良健康影响甚至死亡。实时直接分析质谱法（DART-MS）是一种常压电离方法，用于在无需任何提取或预处理的情况下快速鉴定各种样品中DMAA的存在。DMAA首先在以固体形式直接采样的补充剂中被鉴定出来。此外，在48小时内直接在尿液中检测到DMAA，以此作为近期滥用该物质的一种指示手段。DART-MS分析是即时的，再加上与飞行时间质谱仪相关的高质量准确性，能够明确鉴定DMAA的存在。这些特性表明DART-MS是一种极具吸引力的潜在替代筛查方法，可用于药物和药品的检测或毒理学调查。
