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通过实时飞行时间质谱直接分析快速检测丁氧羰基甲基苯丙胺。

Rapid detection of -butoxycarbonyl-methamphetamine by direct analysis in real time time-of-flight mass spectrometry.

作者信息

Sugie Ken-Ichi, Kurakami Daisuke, Akutsu Mamoru, Saito Koichi

机构信息

1Narcotics Control Department, Kanto-Shin'etsu Regional Bureau of Health and Welfare Ministry of Health, Labour and Welfare, 1-2-1 Kudan-Minami, Chiyoda-ku, Tokyo, 102-8309 Japan.

Narcotics Control Department, Tohoku Regional Bureau of Health and Welfare Ministry of Health, Labour and Welfare, 3-2-23 Honchou, Aoba, Sendai, 980-0014 Japan.

出版信息

Forensic Toxicol. 2018;36(2):261-269. doi: 10.1007/s11419-017-0400-y. Epub 2018 Jan 12.

DOI:10.1007/s11419-017-0400-y
PMID:29963202
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6002434/
Abstract

PURPOSE

Phenethylamines constitute the majority of drug-related arrests in Japan. Recently, the smuggling of -butoxycarbonyl (-Boc)-protected phenethylamines has become of increasing concern, because of the difficult identification of these masked substances.

METHODS

In this study, a rapid and accurate method for the detection of -Boc-methamphetamine (-Boc-MP) by direct analysis in real time-time-of-flight-mass spectrometry (DART-TOF-MS) was developed. The efficiency of the method was evaluated by comparison with conventional gas chromatography-MS (GC-MS) and liquid chromatography-TOF-MS (LC-TOF-MS) techniques.

RESULTS

During GC-MS analysis of -Boc-MP, MP was generated in the injection port, which can lead to an analytical error. In the LC-TOF-MS spectrum, fragment ions were detected, which were generated by McLafferty rearrangement in the ion source. On the other hand, in the DART-TOF-MS analysis of -Boc-MP, pyrolysis could be suppressed by using a micro-syringe injection method, and the fragment ions generated by McLafferty rearrangement were still observed. Moreover, protonated -Boc-MP could be detected.

CONCLUSIONS

Hence, DART-TOF-MS provides a rapid and accurate method for the detection of -Boc-MP, allowing suppression of the pyrolysis reaction and identification of both fragment ions and protonated -Boc-MP. To our knowledge, this is the first report for detecting -Boc-MP by MS techniques.

摘要

目的

苯乙胺类物质构成了日本与毒品相关逮捕案的主要部分。近来，由于难以识别这些被掩盖的物质，叔丁氧羰基（-Boc）保护的苯乙胺类物质的走私问题日益受到关注。

方法

在本研究中，开发了一种通过实时直接分析飞行时间质谱法（DART-TOF-MS）快速准确检测叔丁氧羰基甲基苯丙胺（-Boc-MP）的方法。通过与传统气相色谱-质谱法（GC-MS）和液相色谱-飞行时间质谱法（LC-TOF-MS）技术进行比较，评估了该方法的效率。

结果

在对-Boc-MP进行GC-MS分析时，在进样口中会生成甲基苯丙胺（MP），这可能导致分析误差。在LC-TOF-MS谱图中，检测到了由离子源中的麦克拉弗蒂重排产生的碎片离子。另一方面，在对-Boc-MP进行DART-TOF-MS分析时，使用微量注射器进样法可抑制热解，并且仍然观察到了由麦克拉弗蒂重排产生的碎片离子。此外，还能检测到质子化的-Boc-MP。

结论

因此，DART-TOF-MS为检测-Boc-MP提供了一种快速准确的方法，能够抑制热解反应，并识别碎片离子和质子化的-Boc-MP。据我们所知，这是首次报道用质谱技术检测-Boc-MP。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/8b461f94bc2f/11419_2017_400_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/79265418a10c/11419_2017_400_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/691cdd12d86a/11419_2017_400_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/17f11278a5a8/11419_2017_400_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/7536179a63d1/11419_2017_400_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/7284cfe7e2ad/11419_2017_400_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/5660b018e5f9/11419_2017_400_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/31683388b83a/11419_2017_400_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/8b461f94bc2f/11419_2017_400_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/79265418a10c/11419_2017_400_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/691cdd12d86a/11419_2017_400_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/17f11278a5a8/11419_2017_400_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/7536179a63d1/11419_2017_400_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/7284cfe7e2ad/11419_2017_400_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/5660b018e5f9/11419_2017_400_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/31683388b83a/11419_2017_400_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0df/6002434/8b461f94bc2f/11419_2017_400_Fig8_HTML.jpg

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