Department of Medicine III and Department of Visceral, Thorax, and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19054-8. doi: 10.1073/pnas.1317561110. Epub 2013 Oct 28.
Transplantation of pancreatic islets is emerging as a successful treatment for type-1 diabetes. Its current stringent restriction to patients with critical metabolic lability is justified by the long-term need for immunosuppression and a persistent shortage of donor organs. We developed an oxygenated chamber system composed of immune-isolating alginate and polymembrane covers that allows for survival and function of islets without immunosuppression. A patient with type-1 diabetes received a transplanted chamber and was followed for 10 mo. Persistent graft function in this chamber system was demonstrated, with regulated insulin secretion and preservation of islet morphology and function without any immunosuppressive therapy. This approach may allow for future widespread application of cell-based therapies.
胰岛移植作为一种治疗 1 型糖尿病的有效方法正在兴起。由于长期需要免疫抑制和供体器官持续短缺，目前该方法严格限制在代谢不稳定的患者中。我们开发了一种由免疫隔离藻酸盐和多膜盖组成的充氧室系统，允许胰岛在没有免疫抑制的情况下存活和发挥功能。一名 1 型糖尿病患者接受了移植室治疗，并随访了 10 个月。该室系统持续发挥移植物功能，胰岛素分泌得到调节，胰岛形态和功能得以保存，而无需任何免疫抑制治疗。这种方法可能为未来广泛应用细胞疗法铺平道路。
