大鼠中阿马拉皮塔混合液的抗溃疡活性：一项初步研究。
Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study.
作者信息
Vemula Sampath K, Chawada Mukesh B, Thakur Kapil S, Vahalia Mahesh K
机构信息
Biomedical Services, Shree Dhootapapeshwar Ayurvedic Research Foundation, Navi Mumbai, Maharashtra, India.
出版信息
Anc Sci Life. 2012 Oct;32(2):112-5. doi: 10.4103/0257-7941.118551.
CONTEXT
Amlapitta Mishran suspension is a poly herbal ayurvedic formulation, which has been traditionally used for acidity and gastric ulcers.
AIM
The aim of this study is to evaluate the antiulcer activity of Amlapitta Mishran on non-steroidal anti-inflammatory drugs (NSAID's) -induced ulcers in the rat model.
SUBJECTS AND METHODS
The antiulcer activity of Amlapitta Mishran was investigated on indomethacin (100 mg/kg) NSAID's induced ulcers in rats. Effect of two different doses of Amlapitta Mishran was studied by calculating the total number of ulcers, ulcer index and percentage inhibition.
STATISTICAL ANALYSIS USED
Data was analyzed by the Student's t-test (P < 0.05).
RESULTS
Amlapitta Mishran treated rats have shown significant (P < 0.0001) decrease in the total number of ulcers and ulcer index and significant increase in % inhibition of ulcers as compared with positive control group.
CONCLUSION
The results indicate that Amlapitta Mishran has showed a dose dependent antiulcer activity in experimental animals and confirms ayurvedic use of Amlapitta Mishran in gastric ulcers.
背景
酸泻合剂混悬液是一种多草药阿育吠陀配方制剂，传统上用于治疗胃酸过多和胃溃疡。
目的
本研究旨在评估酸泻合剂对大鼠模型中由非甾体抗炎药（NSAIDs）诱导的溃疡的抗溃疡活性。
对象与方法
研究酸泻合剂对吲哚美辛（100mg/kg）诱导的大鼠NSAIDs溃疡的抗溃疡活性。通过计算溃疡总数、溃疡指数和抑制百分比来研究两种不同剂量酸泻合剂的效果。
所用统计分析方法
数据采用学生t检验进行分析（P<0.05）。
结果
与阳性对照组相比，酸泻合剂治疗的大鼠溃疡总数和溃疡指数显著降低（P<0.0001），溃疡抑制百分比显著增加。
结论
结果表明，酸泻合剂在实验动物中显示出剂量依赖性抗溃疡活性，并证实了酸泻合剂在胃溃疡方面的阿育吠陀用途。
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