School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, Sydney, NSW 2052, Australia.
Dis Markers. 2013;35(1):55-65. doi: 10.1155/2013/476276. Epub 2013 Jul 21.
Autism spectrum disorders (ASD) encompass a range of neurodevelopmental conditions that are clinically and etiologically very heterogeneous. ASD is currently diagnosed entirely on behavioral criteria, but intensive research efforts are focused on identifying biological markers for disease risk and early diagnosis. Here, we discuss recent progress toward identifying biological markers for ASD and highlight specific challenges as well as ethical aspects of translating ASD biomarker research into the clinic.
自闭症谱系障碍（ASD）涵盖了一系列神经发育障碍，这些障碍在临床上和病因学上都非常多样化。ASD 目前完全是根据行为标准来诊断的，但大量的研究工作都集中在确定疾病风险和早期诊断的生物标志物上。在这里，我们讨论了识别 ASD 生物标志物的最新进展，并强调了将 ASD 生物标志物研究转化为临床实践所面临的具体挑战和伦理方面。
