ALDH1A3 阳性和 GPX3 阴性表达是胆囊癌预后不良的生物标志物。

Positive ALDH1A3 and negative GPX3 expressions are biomarkers for poor prognosis of gallbladder cancer.

机构信息

Research Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

出版信息

Dis Markers. 2013;35(3):163-72. doi: 10.1155/2013/187043. Epub 2013 Aug 25.

BACKGROUND

Gallbladder cancers (GBCs) are highly aggressive cancers with high mortality. However, biological markers for the progression and prognosis of GBC are currently unavailable in the clinic.

OBJECTIVE

To identify biomarkers for predicting GBC metastasis and prognosis.

METHODS

We examined ALDH1A3 and GPX3 expressions in 46 squamous cell/adenosquamous carcinomas (SC/ASC) and 80 adenocarcinomas (AC) by using immunohistochemistry.

RESULTS

Positive ALDH1A3 and negative GPX3 expressions were significantly associated with lymph node metastasis and invasion of SC/ASCs and ACs. Univariate Kaplan-Meier analysis showed that either positive ALDH1A3 (P < 0.001) or negative GPX3 (P < 0.001) expression significantly correlated with decreased overall survival in both SC/ASC and AC patients. Multivariate Cox regression analysis showed that positive ALDH1A3 expression or negative GPX3 expression was an independent poor-prognostic predictor in both SC/ASC and AC patients.

CONCLUSIONS

Our study suggested that positive ALDH1A3 and negative GPX3 expressions are closely associated with clinical pathological behaviors and poor prognosis of gallbladder cancer.

背景

胆囊癌（GBC）是一种侵袭性强、死亡率高的癌症。然而，目前临床上尚无用于预测 GBC 进展和预后的生物标志物。

目的

寻找预测 GBC 转移和预后的生物标志物。

方法

我们通过免疫组织化学法检测了 46 例鳞癌/腺鳞癌（SC/ASC）和 80 例腺癌（AC）中 ALDH1A3 和 GPX3 的表达。

结果

ALDH1A3 阳性和 GPX3 阴性表达与 SC/ASCs 和 ACs 的淋巴结转移和浸润显著相关。单因素 Kaplan-Meier 分析显示，ALDH1A3 阳性（P<0.001）或 GPX3 阴性（P<0.001）表达均与 SC/ASC 和 AC 患者的总生存期缩短显著相关。多因素 Cox 回归分析显示，ALDH1A3 阳性表达或 GPX3 阴性表达是 SC/ASC 和 AC 患者独立的预后不良预测因子。