Cho Bongki, Choi So Yoen, Cho Hyo Min, Kim Hyun Jung, Sun Woong
Department of Anatomy, Korea University College of Medicine, Seoul 136-705, Korea.
Exp Neurobiol. 2013 Sep;22(3):149-57. doi: 10.5607/en.2013.22.3.149. Epub 2013 Sep 30.
Mitochondria are essential for proper neuronal morphogenesis and functions, as they are the major source of energy for neural development. The dynamic morphology of mitochondria determines the key functions of mitochondria. Several regulatory proteins such as dynamin-related protein 1 (Drp1) are required to maintain mitochondrial morphology via a balance between continuous fusion and fission. Activity of Drp1, a key regulator in mitochondrial fission, is modulated by multiple post-translation modifications and receptor interactions. In addition, numerous researches have revealed that the regulation of Drp1 activity and mitochondrial dynamics is closely associated with several neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. In this article, we concisely review the recent findings about the biological importance of Drp1-mediated mitochondrial fission in neurons under physiological and pathological conditions.
线粒体对于神经元正常的形态发生和功能至关重要，因为它们是神经发育的主要能量来源。线粒体的动态形态决定了其关键功能。几种调节蛋白，如动力相关蛋白1（Drp1），需要通过持续融合和裂变之间的平衡来维持线粒体形态。Drp1作为线粒体裂变的关键调节因子，其活性受到多种翻译后修饰和受体相互作用的调节。此外，大量研究表明，Drp1活性的调节和线粒体动力学与几种神经退行性疾病密切相关，如阿尔茨海默病和帕金森病。在本文中，我们简要回顾了关于Drp1介导的线粒体裂变在生理和病理条件下对神经元生物学重要性的最新研究结果。
