血清瘦素、脂联素与中国女性子宫内膜癌风险
Serum leptin, adiponectin and endometrial cancer risk in Chinese women.
机构信息
Department of Clinical Laboratory, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
出版信息
J Gynecol Oncol. 2013 Oct;24(4):336-41. doi: 10.3802/jgo.2013.24.4.336. Epub 2013 Oct 2.
OBJECTIVE
To investigate the relationship between serum concentrations of leptin or adiponectin, and endometrial carcinoma in Chinese women.
METHODS
We conducted a case-control study of a total of 516 Chinese women to detect the relationships between serum concentrations of leptin or adiponectin, and endometrial carcinoma in Chinese women. The study subject constituted 206 cases of endometrial cancer and 310 normal controls.
RESULTS
Patients with endometrial carcinoma had higher serum leptin concentrations than controls (28.8±2.2 ug/L vs. 19.8±1.4 ug/L; p<0.001). The adiponectin levels in patients were lower than in controls with borderline statistical significance (2,330.7±180.5 ug/L vs. 2,583.9±147.2 ug/L; p=0.078). Logistic regression analysis confirmed the associations between leptin or adiponectin, and endometrial carcinoma after adjustment for age, body mass index, fasting insulin, serum glucose, cholesterol, triglycerides, and high-density lipoprotein cholesterol (odds ratio for the top tertile vs. the bottom tertile: leptin 2.05; 95% confidence interval [CI], 1.28 to 3.29; p<0.001; adiponectin 0.52; 95% CI, 0.32 to 0.83; p<0.001).
CONCLUSION
Increased leptin or decreased adiponectin levels are associated with endometrial carcinoma.
目的
探讨中国女性血清瘦素或脂联素浓度与子宫内膜癌的关系。
方法
我们进行了一项总计 516 名中国女性的病例对照研究，以检测血清瘦素或脂联素浓度与中国女性子宫内膜癌的关系。研究对象包括 206 例子宫内膜癌患者和 310 例正常对照者。
结果
子宫内膜癌患者的血清瘦素浓度高于对照组（28.8±2.2 ug/L 比 19.8±1.4 ug/L；p<0.001）。患者的脂联素水平低于对照组，但差异有统计学意义（2,330.7±180.5 ug/L 比 2,583.9±147.2 ug/L；p=0.078）。经年龄、体重指数、空腹胰岛素、血清葡萄糖、胆固醇、甘油三酯和高密度脂蛋白胆固醇校正后，logistic 回归分析证实了瘦素或脂联素与子宫内膜癌之间的关联（最高三分位与最低三分位相比的比值比：瘦素 2.05；95%置信区间[CI]，1.28 至 3.29；p<0.001；脂联素 0.52；95%CI，0.32 至 0.83；p<0.001）。
结论
瘦素水平升高或脂联素水平降低与子宫内膜癌相关。
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