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血清维生素D结合蛋白是白蛋白和甲胎蛋白基因家族的第三个成员。

Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family.

作者信息

Cooke N E, David E V

出版信息

J Clin Invest. 1985 Dec;76(6):2420-4. doi: 10.1172/JCI112256.

DOI:10.1172/JCI112256
PMID:2416779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424397/
Abstract

A near full-length cDNA encoding the human vitamin D-binding protein (hDBP) was isolated from a human liver mRNA expression library. Complete sequence analysis of this clone predicts the full-length amino acid sequence of the pre-hDBP. Comparison of the sequence of the hDBP mRNA and protein to existing protein and nucleic acid data banks demonstrates a strong and highly characteristic homology of the hDBP with human albumin (hALB) and human alpha-fetoprotein (hAFP). Based upon this structural comparison, we establish that DBP is a member of the ALB and AFP gene family.

摘要

从人肝脏mRNA表达文库中分离出一个编码人维生素D结合蛋白（hDBP）的近全长cDNA。对该克隆进行完整的序列分析可预测前体hDBP的全长氨基酸序列。将hDBP mRNA和蛋白质的序列与现有的蛋白质和核酸数据库进行比较，结果表明hDBP与人类白蛋白（hALB）和人类甲胎蛋白（hAFP）具有很强且高度特征性的同源性。基于这种结构比较，我们确定DBP是ALB和AFP基因家族的成员。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e5/424397/184f75dd60b3/jcinvest00126-0396-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e5/424397/184f75dd60b3/jcinvest00126-0396-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e5/424397/184f75dd60b3/jcinvest00126-0396-a.jpg

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Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics.正常人和α地中海贫血患者中源自α1和α2珠蛋白基因座的mRNA转录本的分化
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Vitamin D-binding protein (Gc-globulin) binds actin.维生素D结合蛋白（Gc球蛋白）结合肌动蛋白。
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