[林丹及其代谢产物对体外微粒体和线粒体ATP酶的影响]
[The influence of lindane and lindane metabolites on microsomal and mitochondrial ATPase in vitro].
作者信息
Heinevetter D, Lewerenz H J, Plass R, Macholz R
出版信息
J Environ Sci Health B. 1985 Oct;20(5):539-58. doi: 10.1080/03601238509372494.
In vitro investigations of the influence of lindane and its metabolites were performed on microsomal and mitochondrial ATPases from liver, kidney and brain of rat and mouse. The microsomal Na+-K+-ATPases in rat liver were inhibited by the tested substances. An increase of activity was observed only with 2.5 X 10(-5) M gamma-HCH. Effects on the microsomal Na+-K+-ATPase from kidney and brain of rat were also indicated. The mitochondrial enzyme in rat liver was stimulated by all the compounds tested at concentrations of 10(-4) M - 10(-2) M. The effects on mitochondrial enzymes from kidney and brain varied in dependence on the tested substances. In the microsomes and mitochondria of mouse an influence on the Na+-K+-ATPases similar to the effects on the preparations from organs of rat was evident.
对大鼠和小鼠肝脏、肾脏及大脑的微粒体和线粒体ATP酶，进行了林丹及其代谢物影响的体外研究。受试物质抑制了大鼠肝脏微粒体中的Na+-K+-ATP酶。仅在2.5×10(-5)M的γ-六氯环己烷时观察到活性增加。还表明了对大鼠肾脏和大脑微粒体Na+-K+-ATP酶的影响。浓度为10(-4)M - 10(-2)M时，受试的所有化合物均刺激大鼠肝脏中的线粒体酶。对肾脏和大脑线粒体酶的影响因受试物质而异。在小鼠的微粒体和线粒体中，对Na+-K+-ATP酶的影响与对大鼠器官制剂的影响相似，这一点很明显。
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