Mazumder B, Mukherjee S, NagDas S K, Sen P C
Department of Chemistry, Bose Institute, Calcutta, India.
Biochem Int. 1988 Jan;16(1):35-44.
Chloroquine, an antimalarial drug has been found to inhibit Na+, K+-ATPase activity in vitro in the microsomal membranes of rat brain on time, temperature and concentration dependent manner. There have been stimulation of Na+,K+-ATPase, Ca+2-ATPase and acetylcholine esterase activities in vivo studies at lower concentration of drug or shorter period of treatment with the drug, whereas higher concentrations or longer periods of treatment lead to inhibition in the microsomal membranes of different organs.
氯喹，一种抗疟药物，已被发现在体外能以时间、温度和浓度依赖的方式抑制大鼠脑微粒体膜中的钠钾ATP酶活性。在体内研究中，较低浓度的药物或较短的治疗时间会刺激钠钾ATP酶、钙ATP酶和乙酰胆碱酯酶的活性，而较高浓度或较长时间的治疗则会导致不同器官微粒体膜中的酶活性受到抑制。
