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The chlorpromazine inhibition of transport ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vitro and in vivo.

作者信息

Mazumder B, Mukherjee S, Sen P C

机构信息

Department of Chemistry, Bose Institute, Calcutta, India.

出版信息

Mol Cell Biochem. 1990 Jun 1;95(1):13-20. doi: 10.1007/BF00219525.

DOI:10.1007/BF00219525
PMID:2164137
Abstract

Chlorpromazine, an antipsychotic drug, is found to inhibit Na+,K(+)-ATPase activity in rat brain microsomal membranes in vitro in concentration and time dependent manner but some inconsistency is observed when the effect was studied with respect to different temperatures. Various ligands and/or substrate affect the inhibition by chlorpromazine in different ways. The in vivo study with this drug shows that the activities of Na+,K(+)-ATPase, Ca2(+)-ATPase and acetylcholinesterase in the microsomal membranes of different organs are inhibit with increases in concentration or lengths of time of treatment and then levels off.

摘要

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本文引用的文献

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CHEMICAL CODING OF BEHAVIOR IN THE BRAIN.大脑中行为的化学编码
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氯喹对大鼠不同器官转运酶活性的体内抑制作用是可逆的。
Mol Cell Biochem. 1992 Dec 2;118(1):15-21. doi: 10.1007/BF00249690.
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