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在营地环境中进行远程血糖监测可降低夜间低血糖持续时间延长的风险。

Remote glucose monitoring in camp setting reduces the risk of prolonged nocturnal hypoglycemia.

作者信息

DeSalvo Daniel J, Keith-Hynes Patrick, Peyser Thomas, Place Jérôme, Caswell Kim, Wilson Darrell M, Harris Breanne, Clinton Paula, Kovatchev Boris, Buckingham Bruce A

机构信息

1 Stanford University , Stanford, California.

出版信息

Diabetes Technol Ther. 2014 Jan;16(1):1-7. doi: 10.1089/dia.2013.0139. Epub 2013 Oct 29.

Abstract

OBJECTIVE

This study tested the feasibility and effectiveness of remote continuous glucose monitoring (CGM) in a diabetes camp setting.

SUBJECTS AND METHODS

Twenty campers (7-21 years old) with type 1 diabetes were enrolled at each of three camp sessions lasting 5-6 days. On alternating nights, 10 campers were randomized to usual wear of a Dexcom (San Diego, CA) G4™ PLATINUM CGM system, and 10 were randomized to remote monitoring with the Dexcom G4 PLATINUM communicating with the Diabetes Assistant, a cell phone platform, to allow wireless transmission of CGM values. Up to 15 individual graphs and sensor values could be displayed on a single remote monitor or portable tablet. An alarm was triggered for values <70 mg/dL, and treatment was given for meter-confirmed hypoglycemia. The primary end point was to decrease the duration of hypoglycemic episodes <50 mg/dL.

RESULTS

There were 320 nights of CGM data and 197 hypoglycemic events. Of the remote monitoring alarms, 79% were true (meter reading of <70 mg/dL). With remote monitoring, 100% of alarms were responded to, whereas without remote monitoring only 54% of alarms were responded to. The median duration of hypoglycemic events <70 mg/dL was 35 min without remote monitoring and 30 min with remote monitoring (P=0.078). Remote monitoring significantly decreased prolonged hypoglycemic events, eliminating all events <50 mg/dL lasting longer than 30 min as well as all events <70 mg/dL lasting more than 2 h.

CONCLUSIONS

Remote monitoring is feasible at diabetes camps and effective in reducing the risk of prolonged nocturnal hypoglycemia. This technology will facilitate forthcoming studies to evaluate the efficacy of automated closed-loop systems in the camp setting.

摘要

目的

本研究在糖尿病营地环境中测试远程连续血糖监测(CGM)的可行性和有效性。

受试者与方法

在为期5 - 6天的三个营地活动中,每组招募20名1型糖尿病患者(7 - 21岁)。在交替的夜晚,10名参与者被随机分配常规佩戴德康(加利福尼亚州圣地亚哥)G4™ PLATINUM CGM系统,另外10名被随机分配进行远程监测,即德康G4 PLATINUM与手机平台糖尿病助手通信,以实现CGM值的无线传输。单个远程监视器或便携式平板电脑上最多可显示15个个体图表和传感器值。血糖值<70mg/dL时触发警报,对经血糖仪确认的低血糖进行治疗。主要终点是减少血糖<50mg/dL的低血糖发作持续时间。

结果

共有320个夜晚的CGM数据以及197次低血糖事件。远程监测警报中,79%为真(血糖仪读数<70mg/dL)。进行远程监测时,100%的警报得到了响应,而未进行远程监测时,只有54%的警报得到了响应。血糖<70mg/dL的低血糖事件中位持续时间,未进行远程监测时为35分钟,进行远程监测时为30分钟(P = 0.078)。远程监测显著减少了长时间低血糖事件,消除了所有持续超过30分钟的<50mg/dL的事件以及所有持续超过2小时的<70mg/dL的事件。

结论

远程监测在糖尿病营地是可行的,并且在降低夜间长时间低血糖风险方面有效。这项技术将有助于即将开展的研究评估自动闭环系统在营地环境中的疗效。

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