Finnegan A, Hodes R J
J Immunol. 1986 Feb 1;136(3):793-7.
The T suppressor (Ts) cell population that functions to regulate antigen-specific MHC-restricted T helper (Th)-B cell interactions also regulates the activation of B cells by cloned autoreactive Th cells. Activated Ts cells were generated by in vivo priming and restimulation in vitro with high concentrations of the specific priming antigen. Once generated, this Ts population inhibits the Th-dependent activation of primed B cells by both antigen-specific and autoreactive T cells in an antigen-nonspecific manner. This suppression requires the participation of both Lyt-1+2- and Lyt-1-2+ T cells. It was also demonstrated that accessory cells were required for the induction of Ts cells. Moreover, the generation of suppression was MHC-restricted and required the recognition by T cells of Ia antigens on accessory cells. These studies demonstrate that the same or a very similar Ts cell population can function to inhibit the activation of B cells by antigen-specific as well as autoreactive T cells.
具有调节抗原特异性、MHC 限制的 T 辅助（Th）-B 细胞相互作用功能的抑制性 T（Ts）细胞群体，也调节克隆的自身反应性 Th 细胞对 B 细胞的激活。通过体内致敏并用高浓度的特异性致敏抗原进行体外再刺激来产生活化的 Ts 细胞。一旦产生，这个 Ts 细胞群体以抗原非特异性方式抑制由抗原特异性和自身反应性 T 细胞介导的致敏 B 细胞的 Th 依赖性激活。这种抑制需要 Lyt-1+2-和 Lyt-1-2+ T 细胞的参与。还证明诱导 Ts 细胞需要辅助细胞。此外，抑制作用的产生是 MHC 限制的，并且需要 T 细胞识别辅助细胞上的 Ia 抗原。这些研究表明，相同或非常相似的 Ts 细胞群体可以发挥作用，抑制抗原特异性以及自身反应性 T 细胞对 B 细胞的激活。
