School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University , Xuzhou 221116, P. R. China.
J Org Chem. 2013 Nov 15;78(22):11414-20. doi: 10.1021/jo401969g. Epub 2013 Nov 7.
A metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization strategy has been developed for the stereospecific construction with concomitant derivation of biologically significant indolizin-5(1H)-ones from simple and commercial starting materials. The transformations are notable because they can yield five new σ bonds and six stereocenters including a quaternary carbon center in a single operation.
一种无金属的[3+2+1]/[2+2+1]双环化策略已经被开发出来，用于从简单的商业起始原料立体特异性构建并同时衍生具有生物重要性的吲哚嗪-5(1H)-酮。这些转化引人注目，因为它们可以在单步操作中生成五个新的σ键和六个立体中心，包括一个季碳原子中心。
