通过四组分多米诺反应高效合成多取代吡咯。
Highly efficient synthesis of polysubstituted pyrroles via four-component domino reaction.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China, and School of Safety Engineering, China University of Mining & Technology , Xuzhou 221116, P. R. China.
出版信息
Org Lett. 2013 May 17;15(10):2542-5. doi: 10.1021/ol4010382. Epub 2013 May 1.
A highly efficient, catalyst-free synthesis of polysubstituted pyrroles by means of a novel four-component domino reaction of an arylglyoxal monohydrate, an aniline, a dialkyl but-2-ynedioate, and malononitrile is reported. This transformation proceeded via a 6,6a-dihydrofuro[2,3-b]pyrrole as the key intermediate.
一种高效、无催化剂的多取代吡咯合成方法，通过一种新型的芳基乙二醛单水合物、苯胺、二烷基丁-2-炔二酸酯和丙二腈的四组分多米诺反应实现。该转化通过 6,6a-二氢呋喃[2,3-b]吡咯作为关键中间体进行。
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