Centre de Physiopathologie de Toulouse Purpan, Université Toulouse III Paul-Sabatier, Toulouse F-31300, France; INSERM, U1043, Toulouse F-31300, France; CNRS, UMR5282, Toulouse F-31300, France.
Curr Opin Immunol. 2013 Dec;25(6):670-5. doi: 10.1016/j.coi.2013.10.004. Epub 2013 Oct 26.
Type 1 diabetes is a T cell mediated autoimmune disease where both central and peripheral mechanisms effect T cell tolerance induction. Dendritic cells (DCs) are key regulators of innate and adaptive immune responses. They significantly contribute to central and peripheral T cell tolerance and, following maturation, induce the activation and differentiation of naïve T cells into effector and memory cells. DCs are also major actors in inflammation. Given these multiple effects on immune responses, DCs are suspected to contribute to autoimmune diseases. In this review we discuss how some specific features of DC may contribute to type 1 diabetes.
1 型糖尿病是一种 T 细胞介导的自身免疫性疾病，其中中枢和外周机制均影响 T 细胞耐受诱导。树突状细胞（DC）是先天和适应性免疫反应的关键调节剂。它们对中枢和外周 T 细胞耐受有重要贡献，并且在成熟后，诱导初始 T 细胞激活和分化为效应细胞和记忆细胞。DC 也是炎症的主要参与者。鉴于它们对免疫反应的多种影响，DC 被怀疑与自身免疫性疾病有关。在这篇综述中，我们讨论了 DC 的某些特定特征如何导致 1 型糖尿病。
