Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA 94110, United States.
Curr Opin Immunol. 2013 Oct;25(5):593-7. doi: 10.1016/j.coi.2013.09.013. Epub 2013 Oct 27.
The Immunological Genome Consortium has generated a public resource (www.immgen.org) that provides a compendium of gene expression profiles of ∼270 leukocyte subsets in the mouse. This effort established carefully standardized operating procedures that resulted in a transcriptional dataset of unprecedented comprehensiveness and quality. The findings have been detailed recently in a series of publications providing molecular insights into the development, heterogeneity, and/or function of these cellular lineages and distinct subpopulations. Here, we review the key findings of these studies, highlighting what has been gained and how the knowledge can be used to accelerate progress toward a comprehensive understanding of the immune system.
免疫基因组联盟（Immunological Genome Consortium）已经创建了一个公共资源（www.immgen.org），提供了约 270 种小鼠白细胞亚群的基因表达谱汇编。该工作建立了精心标准化的操作程序，产生了一个具有空前全面性和质量的转录数据集。这些发现最近在一系列出版物中得到了详细阐述，这些出版物为这些细胞谱系和不同亚群的发育、异质性和/或功能提供了分子见解。在这里，我们回顾了这些研究的主要发现，强调了所取得的成果以及如何利用这些知识来加速对免疫系统的全面理解。
